Felipe Morales

00:47

Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals

Andrés Opazo-Capurro ,

Iván San Martín ,

Mario Quezada-Aguiluz ,

Felipe Morales ,

Mariana Domínguez-Yévenes ,

Celia A. Lima ,

Fernanda Esposito ,

Louise Cerdeira ,

Helia Bello-Toledo ,

Nilton Lincopan ,

Gerardo González-Rocha

Infection, Genetics and Evolution, 2019-04-25

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Infection, Genetics and Evolution

We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-blaOXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109 (CC1), ST162 (CC79), ST15 (CC15) and ST318 (CC15).

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Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals