Author(s)
Jenna J. Guthmiller
Published 6 Projects
Immunology Microbiology Infectious Diseases Influenza Hemagglutinin Stalk
Olivia Stovicek
Published 4 Projects
Immunology Microbiology Infectious Diseases Influenza Hemagglutinin Stalk
Siriruk Changrob
Published 3 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Nai-Ying Zheng
Published 4 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Christopher T. Stamper
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Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Haley L. Dugan
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Min Huang
Published 5 Projects
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Content
Video Abstract (AI generated) (01:24) Paper Preprint Supplemental Figures Supplemental Tables 1, 3, 5Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity and kinetics of the antibody response mounted against this novel virus are not understood in detail. Here, we report that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and non-structural proteins. Subjects with a greater antibody response mounted a larger memory B cell response against the spike, but not the nucleocapsid protein. Additionally, we revealed that antibodies against the spike are still capable of binding the D614G spike mutant and cross-react with the SARS-CoV-1 receptor binding domain. Together, this study reveals that subjects with a more severe SARS-CoV-2 infection exhibit a greater overall antibody response to the spike and nucleocapsid protein and a larger memory B cell response against the spike. ### Competing Interest Statement The authors have declared no competing interest.
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Patrick Wilson. (2021, Oct 29).SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike[Video]. Scitok. https://scitok.com/project/p/022032e3
J. Guthmiller Jenna. "SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike" Scitok, uploaded by Wilson Patrick, 29 Oct, 2021, https://scitok.com/project/p022032e3
Patrick Wilson. "SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike" Scitok. (Oct 29, 2021). https://scitok.com/project/p/022032e3
Patrick Wilson (Oct 29, 2021). SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike Scitok. https://scitok.com/project/p/022032e3
Patrick Wilson. SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike[video]. 2021 Oct 29. https://scitok.com/project/p/022032e3
@online{al2006link, title={ SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike }, author={ Wilson, Patrick }, organization={Scitok}, month={ Oct }, day={ 29 }, year={ 2021 }, url = {https://scitok.com/project/p/022032e3}, }