Author(s)
Greg McInnes
Published 5 Projects
genomics Bioinformatics Genetics Health Systems And Quality Improvement
Russ Altman
Published 17 Projects
Through Manual Identification And Other In The United States In This Paper Singapore
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Video Abstract (AI generated) (01:08) Paper Preprint Supplemental File 1 Supplemental FiguresPharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), but the broad impact of genetic variation on entire populations is not well-understood. We analyzed PGx allele and phenotype frequencies for 487,409 participants in the U.K. Biobank, the largest PGx study to date. For fourteen CPIC pharmacogenes known to influence human drug response, we find that 99.5% of individuals may have an atypical response to at least one drug; on average they may have an atypical response to 12 drugs. Non-European populations carry a greater frequency of variants that are predicted to be functionally deleterious; many of these are not captured by current PGx allele definitions. Strategies for detecting and interpreting rare variation will be critical for enabling broad application of pharmacogenetics. ### Competing Interest Statement R.B.A. is a stockholder in Personalis.com, 23andme.com.
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Russ Altman. (2021, Oct 26).Pharmacogenetics at scale: An analysis of the UK Biobank[Video]. Scitok. https://scitok.com/project/p/0796dd8a
McInnes Greg. "Pharmacogenetics at scale: An analysis of the UK Biobank" Scitok, uploaded by Altman Russ, 26 Oct, 2021, https://scitok.com/project/p0796dd8a
Russ Altman. "Pharmacogenetics at scale: An analysis of the UK Biobank" Scitok. (Oct 26, 2021). https://scitok.com/project/p/0796dd8a
Russ Altman (Oct 26, 2021). Pharmacogenetics at scale: An analysis of the UK Biobank Scitok. https://scitok.com/project/p/0796dd8a
Russ Altman. Pharmacogenetics at scale: An analysis of the UK Biobank[video]. 2021 Oct 26. https://scitok.com/project/p/0796dd8a
@online{al2006link, title={ Pharmacogenetics at scale: An analysis of the UK Biobank }, author={ Altman, Russ }, organization={Scitok}, month={ Oct }, day={ 26 }, year={ 2021 }, url = {https://scitok.com/project/p/0796dd8a}, }