Author(s)
Matthieu Schapira
Associate Professor, University of Toronto
Published 8 Projects
Bioinformatics Biochemistry Pharmacology And Toxicology Cell Biology
Content
Video Abstract (AI generated) (01:10) Paper Preprint Nature CommunicationsProtein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs in cellular studies. Our collection provides inhibitors and antagonists that together modulate most of the key regulatory methylation marks on histones H3 and H4, providing an important resource for modulating cellular epigenomes. We describe a comprehensive and comparative characterization of the probe collection with respect to their potency, selectivity, and mode of inhibition. We demonstrate the utility of this collection in CD4+ T cell differentiation assays revealing the remarkable potential of individual probes to alter multiple T cell subpopulations with important implications for T cell-mediated processes such as inflammation and immuno-oncology. In particular, we demonstrate a role for DOT1L in limiting Th1 cell differentiation and maintaining lineage integrity.
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Fengling Li. (2021, Sep 30).A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling[Video]. Scitok. https://scitok.com/project/p/0a4b1600
Scheer Sebastian. "A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling" Scitok, uploaded by Li Fengling, 30 Sep, 2021, https://scitok.com/project/p0a4b1600
Fengling Li. "A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling" Scitok. (Sep 30, 2021). https://scitok.com/project/p/0a4b1600
Fengling Li (Sep 30, 2021). A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling Scitok. https://scitok.com/project/p/0a4b1600
Fengling Li. A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling[video]. 2021 Sep 30. https://scitok.com/project/p/0a4b1600
@online{al2006link, title={ A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling }, author={ Li, Fengling }, organization={Scitok}, month={ Sep }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/0a4b1600}, }