Antibiotics effects on the fecal metabolome in preterm infants

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Author Name

Laura Patton

Nan Li

J. Lauren Ruoss

Jordan T. Russell

Diomel de la Cruz

Catalina Bazacliu

Richard A. Polin

Eric W. Triplett

Josef Neu

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Within a randomized prospective pilot study of preterm infants born less than 33 weeks gestation, fecal samples were collected weekly and metabolomic analysis was performed. The objective is to evaluate for differences in fecal metabolites in infants exposed to antibiotics vs not exposed to antibiotics in the first 48hours after birth. Significant differences were seen in the antibiotics vs no antibiotics group, including pathways related to vitamin biosynthesis, bile acids, amino acid metabolism and neurotransmitters. Early antibiotic exposure in preterm infants may alter metabolites in the intestinal tract of preterm infants. Broader multi-omic studies that address mechanisms will guide more prudent antibiotic use in this population. ### Competing Interest Statement Dr. Josef Neu is the principal investigator of a study with Infant Bacterial Therapeutics and on the Scientific Advisory Boards of Medela and Astarte. No other authors have conflicts of interest to disclose.

Antibiotics 1 Project
Microbiology 111 Projects
Preterm Infants
Preterm Infants 1 Project
Metabolome 1 Project