Author(s)
Natalia A. Bulgakova
Published 5 Projects
Cell Biology Developmental Biology Endocytosis Rhoa E Cadherin
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Video Abstract (AI generated) (00:52) Paper PreprintCells rely on molecular motors moving along an ever-shifting network of polymers (microtubules) for the targeted delivery of cell organelles to biologically-relevant locations. We present a stochastic model for a molecular motor stepping along a bidirectional bundle of microtubules, as well as a tractable analytical model. Using these models, we investigate how the preferred stepping direction of the motor (parallel or antiparallel to the microtubule growth, corresponding to kinesin and dynein motor families) quantitatively and qualitatively affects the cargo delivery. We predict which motor type is responsible for which cargo type, given the experimental distribution of cargo in the cell, and report experimental findings which support this guideline for motor classification.
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Danny Reinberg. (2021, Nov 7).The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles[Video]. Scitok. https://scitok.com/project/p/0b4b3b38
Zhelezov Gleb. "The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles" Scitok, uploaded by Reinberg Danny, 7 Nov, 2021, https://scitok.com/project/p0b4b3b38
Danny Reinberg. "The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles" Scitok. (Nov 7, 2021). https://scitok.com/project/p/0b4b3b38
Danny Reinberg (Nov 7, 2021). The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles Scitok. https://scitok.com/project/p/0b4b3b38
Danny Reinberg. The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles[video]. 2021 Nov 7. https://scitok.com/project/p/0b4b3b38
@online{al2006link, title={ The walkoff effect: cargo distribution implies motor type in bidirectional microtubule bundles }, author={ Reinberg, Danny }, organization={Scitok}, month={ Nov }, day={ 7 }, year={ 2021 }, url = {https://scitok.com/project/p/0b4b3b38}, }