Brain age relates to early life factors but not to accelerated brain aging

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Author(s)

Author Name

Didac Vidal-Pineiro

Uploader

Yunpeng Wang

Stine K Krogsrud

Inge K Amlien

William FC Baare

David Bartres-Faz

Lars Bertram

Published 4 Projects

Neuroscience Hippocampus Memory Genetics Mri

Andreas M Brandmaier

Christian A Drevon

Sandra Duzel

Klaus P. Ebmeier

Rik N Henson

Carme Junque

Rogier Kievit

Simone Kuhn

Esten Leonardsen

Ulman Lindenberger

Kathrine S Madsen

Fredrik Magnussen

Athanasia M. Mowinckel

Published 4 Projects

Neuroscience Hippocampus Brain Genetics Mri

Lars Nyberg

James M. Roe

Barbara Segura

Oystein Sorensen

Published 4 Projects

Neuroscience Hippocampus Brain Genetics Mri

Sana Suri

Eniko Zsoldos

AIBL

Kristine B. Walhovd

Anders M. Fjell

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Brain age is an influential index for quantifying brain health, assumed partially to reflect the rate of brain aging. We explicitly tested this assumption in two large datasets and found no association between cross-sectional brain age and steeper brain decline. Rather, brain age in adulthood was associated with early-life influences indexed by birth weight and polygenic scores. The results call for nuanced interpretations of cross-sectional indices of the aging brain.

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