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Antibodies are becoming a frontline therapy for SARS-CoV-2, but the risk of viral evolutionary escape remains unclear. Here we map how all mutations to SARS-CoV-2's receptor-binding domain (RBD) affect binding by the antibodies in Regeneron's REGN-COV2 cocktail and Eli Lilly's LY-CoV016. These complete maps uncover a single amino-acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2, as well as in lab viral escape selections. Finally, the maps reveal that mutations escaping each individual antibody are already present in circulating SARS-CoV-2 strains. Overall, these complete escape maps enable immediate interpretation of the consequences of mutations observed during viral surveillance.
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Tyler N Starr. (2021, Oct 29).Prospective mapping of viral mutations that escape antibodies used to treat COVID-19[Video]. Scitok. https://scitok.com/project/p/0df08728
N Starr Tyler. "Prospective mapping of viral mutations that escape antibodies used to treat COVID-19" Scitok, uploaded by N Starr Tyler, 29 Oct, 2021, https://scitok.com/project/p0df08728
Tyler N Starr. "Prospective mapping of viral mutations that escape antibodies used to treat COVID-19" Scitok. (Oct 29, 2021). https://scitok.com/project/p/0df08728
Tyler N Starr (Oct 29, 2021). Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 Scitok. https://scitok.com/project/p/0df08728
Tyler N Starr. Prospective mapping of viral mutations that escape antibodies used to treat COVID-19[video]. 2021 Oct 29. https://scitok.com/project/p/0df08728
@online{al2006link, title={ Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 }, author={ N Starr, Tyler }, organization={Scitok}, month={ Oct }, day={ 29 }, year={ 2021 }, url = {https://scitok.com/project/p/0df08728}, }