Author(s)
Natalia Kudryavtseva
Published 4 Projects
Neuroscience Chronic Social Defeat Stress Lithium Chloride Drsci Prof Kudryavtseva Nn
Irina L. Kovalenko
Published 3 Projects
Neuroscience Chronic Social Defeat Stress Lithium Chloride Drsci Prof Kudryavtseva Nn
Dmitry A Smagin
Published 3 Projects
Neuroscience Chronic Social Defeat Stress Lithium Chloride Drsci Prof Kudryavtseva Nn
Anna G Galyamina
Published 1 Project
Neuroscience Communication Autistic Genes Abnormal Social Behavior Low
Vladimir N Babenko
Published 3 Projects
Neuroscience Communication Autistic Genes Abnormal Social Behavior Low
Content
Video Abstract (AI generated) (02:44) Paper PreprintBackground: The ability of people to communicate with each other is a necessary component of social behavior and the normal development of individuals who live in a community. An apparent decline in sociability may be the result of a negative social environment or the development of affective and neurological disorders, including autistic spectrum disorders. The behavior of these humans may be characterized by the deterioration of socialization, low communication, and repetitive and restricted behaviors. This study aimed to analyze changes in the social behaviors of male mice induced by daily agonistic interactions and investigate the involvement of genes, related with autistic spectrum disorders in the process of the impairment of social behaviors. Methods: Abnormal social behavior is induced by repeated experiences of aggression accompanied by wins (winners) or chronic social defeats (losers) in daily agonistic interactions in male mice. The collected brain regions (the midbrain raphe nuclei, ventral tegmental area, striatum, hippocampus, and hypothalamus) were sequenced at JSC Genoanalytica (http://genoanalytica.ru/, Moscow, Russia). The Cufflinks program was used to estimate the gene expression levels. Bioinformatic methods were used for the analysis of differentially expressed genes in male mice. Results: The losers exhibited an avoidance of social contacts toward unfamiliar conspecific, immobility and low communication on neutral territory. The winners demonstrated aggression and hyperactivity in this condition. The exploratory activity (rearing) and approaching behavior time towards the partner were decreased, and the number of episodes of repetitive self-grooming behavior was increased in both social groups. These symptoms were similar to the symptoms observed in animal models of autistic spectrum disorders. In an analysis of the RNA-Seq database of the whole transcriptome in the brain regions of the winners and losers, we identified changes in the expression of the following genes, which are associated with autism in humans: Tph2, Maoa, Slc6a4, Htr7, Gabrb3, Nrxn1, Nrxn2, Nlgn1, Nlgn2, Nlgn3, Shank2, Shank3, Fmr1, Ube3a, Pten, Cntn3, Foxp2, Oxtr, Reln, Cadps2, Pcdh10, Ctnnd2, En2, Arx, Auts2, Mecp2, and Ptchd1. Common and specific changes in the expression of these genes in different brain regions were identified in the winners and losers. Conclusions: This research demonstrates for the first time that abnormalities in social behaviors that develop under a negative social environment in adults may be associated with alterations in expression of genes, related with autism in the brain.
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Natalia Kudryavtseva. (2021, Nov 1).Abnormal Social Behaviors And Dysfunction Of Autism-Related Genes Associated With Daily Agonistic Interactions In Mice[Video]. Scitok. https://scitok.com/project/p/0fab8090
Kudryavtseva Natalia. "Abnormal Social Behaviors And Dysfunction Of Autism-Related Genes Associated With Daily Agonistic Interactions In Mice" Scitok, uploaded by Kudryavtseva Natalia, 1 Nov, 2021, https://scitok.com/project/p0fab8090
Natalia Kudryavtseva. "Abnormal Social Behaviors And Dysfunction Of Autism-Related Genes Associated With Daily Agonistic Interactions In Mice" Scitok. (Nov 1, 2021). https://scitok.com/project/p/0fab8090
Natalia Kudryavtseva (Nov 1, 2021). Abnormal Social Behaviors And Dysfunction Of Autism-Related Genes Associated With Daily Agonistic Interactions In Mice Scitok. https://scitok.com/project/p/0fab8090
Natalia Kudryavtseva. Abnormal Social Behaviors And Dysfunction Of Autism-Related Genes Associated With Daily Agonistic Interactions In Mice[video]. 2021 Nov 1. https://scitok.com/project/p/0fab8090
@online{al2006link, title={ Abnormal Social Behaviors And Dysfunction Of Autism-Related Genes Associated With Daily Agonistic Interactions In Mice }, author={ Kudryavtseva, Natalia }, organization={Scitok}, month={ Nov }, day={ 1 }, year={ 2021 }, url = {https://scitok.com/project/p/0fab8090}, }