Author(s)
Sarah E Morgan
Published 5 Projects
Neuroscience Psychiatry And Clinical Psychology Natural Language Processing Schizophrenia Psychosis
Kirstie J. Whitaker
Published 7 Projects
Neuroscience Structure 1. Introduction Gene Expression Schizophrenia
Philip McGuire
Published 2 Projects
Neuroscience Psychiatry And Clinical Psychology Natural Language Processing Psychosis Speech
Petra E VĂ©rtes
Published 13 Projects
Neuroscience Psychiatry And Clinical Psychology Structure 1. Introduction Natural Language Processing
Edward T. Bullmore
Published 11 Projects
Neuroscience Structure 1. Introduction Gene Expression Schizophrenia
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Video Abstract (AI generated) (01:46) Paper Preprint Proceedings of the National Academy of SciencesSchizophrenia has been conceived as a disorder of brain connectivity but it is unclear how this network phenotype is related to the emerging genetics. We used morphometric similarity analysis of magnetic resonance imaging (MRI) data as a marker of inter-areal cortical connectivity in three prior case-control studies of psychosis: in total, N=185 cases and N=227 controls. Psychosis was associated with globally reduced morphometric similarity (MS) in all 3 studies. There was also a replicable pattern of case-control differences in regional MS which was significantly reduced in patients in frontal and temporal cortical areas, but increased in parietal cortex. Using prior brain-wide gene expression data, we found that the cortical map of case-control differences in MS was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms and pathways. In addition, genes that were normally over-expressed in cortical areas with reduced MS were significantly up-regulated in a prior post mortem study of schizophrenia. We propose that this combination of neuroimaging and transcriptional data provides new insight into how previously implicated genes and proteins, as well as a number of unreported proteins in their vicinity on the protein interaction network, may interact to drive structural brain network changes in schizophrenia.
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Petra E VĂ©rtes. (2021, Nov 9).Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes[Video]. Scitok. https://scitok.com/project/p/117892e2
E Morgan Sarah. "Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes" Scitok, uploaded by E VĂ©rtes Petra, 9 Nov, 2021, https://scitok.com/project/p117892e2
Petra E VĂ©rtes. "Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes" Scitok. (Nov 9, 2021). https://scitok.com/project/p/117892e2
Petra E VĂ©rtes (Nov 9, 2021). Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes Scitok. https://scitok.com/project/p/117892e2
Petra E VĂ©rtes. Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes[video]. 2021 Nov 9. https://scitok.com/project/p/117892e2
@online{al2006link, title={ Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes }, author={ E VĂ©rtes, Petra }, organization={Scitok}, month={ Nov }, day={ 9 }, year={ 2021 }, url = {https://scitok.com/project/p/117892e2}, }