Author(s)
Xueyong Zhu
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Ian A. Wilson
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Content
Video Abstract (AI generated) (01:16) Paper Preprint Acta Neuropathologica CommunicationsMisfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated VH5-51/VL4-1 antibodies. One of these, CBTAU-27.1, binds to the aggregation motif in the R3 repeat domain and blocks the aggregation of tau into paired helical filaments (PHFs) by sequestering monomeric tau. The other, CBTAU-28.1, binds to the N-terminal insert region and inhibits the spreading of tau seeds and mediates the uptake of tau aggregates into microglia by binding PHFs. Crystal structures revealed that the combination of VH5-51 and VL4-1 recognizes a common Pro-Xn-Lys motif driven by germline-encoded hotspot interactions while the specificity and thereby functionality of the antibodies are defined by the CDR3 regions. Affinity improvement led to improvement in functionality, identifying their epitopes as new targets for therapy and prevention of AD.
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Xueyong Zhu. (2021, Nov 6).Common antigenic motif recognized by human VH5-51 VL4-1 tau antibodies with distinct functionalities[Video]. Scitok. https://scitok.com/project/p/12270349
Apetri Adrian. "Common antigenic motif recognized by human VH5-51 VL4-1 tau antibodies with distinct functionalities" Scitok, uploaded by Zhu Xueyong, 6 Nov, 2021, https://scitok.com/project/p12270349
Xueyong Zhu. "Common antigenic motif recognized by human VH5-51 VL4-1 tau antibodies with distinct functionalities" Scitok. (Nov 6, 2021). https://scitok.com/project/p/12270349
Xueyong Zhu (Nov 6, 2021). Common antigenic motif recognized by human VH5-51 VL4-1 tau antibodies with distinct functionalities Scitok. https://scitok.com/project/p/12270349
Xueyong Zhu. Common antigenic motif recognized by human VH5-51 VL4-1 tau antibodies with distinct functionalities[video]. 2021 Nov 6. https://scitok.com/project/p/12270349
@online{al2006link, title={ Common antigenic motif recognized by human VH5-51 VL4-1 tau antibodies with distinct functionalities }, author={ Zhu, Xueyong }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/12270349}, }