Author(s)
Xueyong Zhu
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Ian A. Wilson
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Content
Video Abstract (AI generated) (01:05) Paper Preprint Supplementary Materials ScienceThe outbreak of COVID-19, which is caused by SARS-CoV-2 virus, continues to spread globally, but there is currently very little understanding of the epitopes on the virus. In this study, we have determined the crystal structure of the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein in complex with CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient. CR3022 targets a highly conserved epitope that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding site can only be accessed when at least two RBDs on the trimeric S protein are in the ″up″ conformation. Overall, this study provides structural and molecular insight into the antigenicity of SARS-CoV-2.
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Xueyong Zhu. (2021, Nov 6).A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV[Video]. Scitok. https://scitok.com/project/p/12858ef9
Yuan Meng. "A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV" Scitok, uploaded by Zhu Xueyong, 6 Nov, 2021, https://scitok.com/project/p12858ef9
Xueyong Zhu. "A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV" Scitok. (Nov 6, 2021). https://scitok.com/project/p/12858ef9
Xueyong Zhu (Nov 6, 2021). A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV Scitok. https://scitok.com/project/p/12858ef9
Xueyong Zhu. A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV[video]. 2021 Nov 6. https://scitok.com/project/p/12858ef9
@online{al2006link, title={ A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV }, author={ Zhu, Xueyong }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/12858ef9}, }