Author(s)
Xueyong Zhu
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Ian A. Wilson
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Content
The outbreak of COVID-19, which is caused by SARS-CoV-2 virus, continues to spread globally, but there is currently very little understanding of the epitopes on the virus. In this study, we have determined the crystal structure of the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein in complex with CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient. CR3022 targets a highly conserved epitope that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding site can only be accessed when at least two RBDs on the trimeric S protein are in the ″up″ conformation. Overall, this study provides structural and molecular insight into the antigenicity of SARS-CoV-2.
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Xueyong Zhu. (2021, Nov 6).A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV[Video]. Scitok. https://scitok.com/project/p/12858ef9
Yuan Meng. "A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV" Scitok, uploaded by Zhu Xueyong, 6 Nov, 2021, https://scitok.com/project/p12858ef9
Xueyong Zhu. "A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV" Scitok. (Nov 6, 2021). https://scitok.com/project/p/12858ef9
Xueyong Zhu (Nov 6, 2021). A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV Scitok. https://scitok.com/project/p/12858ef9
Xueyong Zhu. A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV[video]. 2021 Nov 6. https://scitok.com/project/p/12858ef9
@online{al2006link, title={ A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV }, author={ Zhu, Xueyong }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/12858ef9}, }