Author(s)
Randy A. Albrecht
Published 2 Projects
Microbiology Infectious Diseases Key Words Influenza A Virus Next
Fatima Amanat
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Infectious Diseases Epidemiology Allergy And Immunology Immunology Covid19
Adolfo GarcĂa-Sastre
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COVID-19 Microbiology Biochemistry Infectious Diseases Allergy And Immunology
Peter Palese
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Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Content
Video Abstract (AI generated) (01:12) Paper PreprintA successful SARS-CoV-2 vaccine must be not only safe and protective but must also meet the demand on a global scale at low cost. Using the current influenza virus vaccine production capacity to manufacture an egg-based inactivated Newcastle disease virus (NDV)/SARS-CoV-2 vaccine would meet that challenge. Here, we report pre-clinical evaluations of an inactivated NDV chimera stably expressing the membrane-anchored form of the spike (NDV-S) as a potent COVID-19 vaccine in mice and hamsters. The inactivated NDV-S vaccine was immunogenic, inducing strong binding and/or neutralizing antibodies in both animal models. More importantly, the inactivated NDV-S vaccine protected animals from SARS-CoV-2 infections or significantly attenuated SARS-CoV-2 induced disease. In the presence of an adjuvant, antigen-sparing could be achieved, which would further reduce the cost while maintaining the protective efficacy of the vaccine. ### Competing Interest Statement The authors have declared no competing interest.
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Florian Krammer. (2021, Oct 30).A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine[Video]. Scitok. https://scitok.com/project/p/146e3c03
Sun Weina. "A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/p146e3c03
Florian Krammer. "A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine" Scitok. (Oct 30, 2021). https://scitok.com/project/p/146e3c03
Florian Krammer (Oct 30, 2021). A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine Scitok. https://scitok.com/project/p/146e3c03
Florian Krammer. A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine[video]. 2021 Oct 30. https://scitok.com/project/p/146e3c03
@online{al2006link, title={ A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/146e3c03}, }