Author(s)
Xueyong Zhu
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Ian A. Wilson
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Content
Video Abstract (AI generated) (01:23) Paper PreprintCombinatorial antibody libraries not only effectively reduce antibody discovery to a numbers game, but enable documentation of the history of antibody responses in an individual. The SARS-CoV-2 pandemic has prompted a wider application of this technology to meet the public health challenge of pandemic threats in the modern era. Herein, we used a combinatorial human antibody library constructed 20 years before the COVID-19 pandemic to discover three highly potent antibodies that selectively bind SARS-CoV-2 spike protein and neutralize authentic SARS-CoV-2 virus. Compared to neutralizing antibodies from COVID-19 patients with generally low somatic hypermutation (SHM), these antibodies contain over 13-22 SHMs, many of which are involved in specific interactions in crystal structures with SARS-CoV-2 spike RBD. The identification of these somatically mutated antibodies in a pre-pandemic library raises intriguing questions about the origin and evolution of human immune responses to SARS-CoV-2. ### Competing Interest Statement The authors have declared no competing interest.
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Xueyong Zhu. (2021, Nov 6).Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago[Video]. Scitok. https://scitok.com/project/p/17d6ae4e
Qiang Min. "Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago" Scitok, uploaded by Zhu Xueyong, 6 Nov, 2021, https://scitok.com/project/p17d6ae4e
Xueyong Zhu. "Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago" Scitok. (Nov 6, 2021). https://scitok.com/project/p/17d6ae4e
Xueyong Zhu (Nov 6, 2021). Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago Scitok. https://scitok.com/project/p/17d6ae4e
Xueyong Zhu. Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago[video]. 2021 Nov 6. https://scitok.com/project/p/17d6ae4e
@online{al2006link, title={ Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago }, author={ Zhu, Xueyong }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/17d6ae4e}, }