Brain-behaviour modes of covariation in healthy and clinically depressed young people

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Author(s)

Author Name

Agoston Mihalik

Published 1 Project

Neuroscience

Fabio S Ferreira

Published 1 Project

Neuroscience

Maria J Rosa

Published 1 Project

Neuroscience

Michael Moutoussis

Published 1 Project

Neuroscience

Joao M Monteiro

Published 1 Project

Neuroscience

Liana Portugal

Published 1 Project

Neuroscience

Rick A Adams

Published 1 Project

Neuroscience

Rafael Romero-Garcia

František Váša

Peter Fonagy

Ian M. Goodyer

Peter B. Jones

NSPN Consortium

Published 1 Project

Neuroscience

Raymond Dolan

Published 1 Project

Neuroscience

Janaina Mourao-Miranda

Published 1 Project

Neuroscience

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Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is a major challenge. This has particular relevance for mental health disorders where a failure to understand these links might hinder the development of better diagnostic approaches and therapeutics. Here, we investigated this question in 306 adolescents and young adults (14-24y, 25 clinically depressed) using a multivariate statistical framework, based on canonical correlation analysis (CCA). By linking individual functional brain connectivity profiles to self-report questionnaires, IQ and demographic data we identified two distinct modes of covariation. The first mode mapped onto an externalization/internalization axis and showed a strong association with sex. The second mode mapped onto a well-being/distress axis independent of sex. Interestingly, both modes showed an association with age. Crucially, the changes in functional brain connectivity associated with changes in these phenotypes showed marked developmental effects. The findings point to a role for the default mode, frontoparietal and limbic networks in psychopathology and depression.

Neuroscience
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