Author(s)
Joshua Galanter
Published 6 Projects
Epidemiology Genetics Key Words Pharmacogenomics Scientific Communication And Education
Sam Oh
Published 5 Projects
Epidemiology Genetics Key Words Pharmacogenomics Scientific Communication And Education
Konstantin Strauch
Published 5 Projects
genomics Genetics Genetic And Genomic Medicine Sexual And Reproductive Health
Harald Grallert
Published 4 Projects
genomics Genetics Genetic And Genomic Medicine Sexual And Reproductive Health
Thomas Meitinger
Published 7 Projects
genomics Genetics Genetic And Genomic Medicine Sexual And Reproductive Health
Christian Gieger
Published 7 Projects
genomics Genetics Genetic And Genomic Medicine Sexual And Reproductive Health
Content
Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In contrast, it is not clear to what extent population structure is captured by whole-genome DNA methylation data. We demonstrate, using three large cohort 450K methylation array data sets, that ancestry information signal is mirrored in genome-wide DNA methylation data, and that it can be further isolated more effectively by leveraging the correlation structure of CpGs with cis-located SNPs. Based on these insights, we propose a method, EPISTRUCTURE, for the inference of ancestry from methylation data, without the need for genotype data. EPISTRUCTURE can be used to infer ancestry information of individuals based on their methylation data in the absence of corresponding genetic data. Although genetic data are often collected in epigenetic studies of large cohorts, these are typically not made publicly available, making the application of EPISTRUCTURE especially useful for anyone working on public data. Implementation of EPISTRUCTURE is available in GLINT, our recently released toolset for DNA methylation analysis at: http://glint-epigenetics.readthedocs.io.
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Joshua Galanter. (2021, Nov 6).Genome-wide methylation data mirror ancestry information[Video]. Scitok. https://scitok.com/project/p/29d6a91f
Rahmani Elior. "Genome-wide methylation data mirror ancestry information" Scitok, uploaded by Galanter Joshua, 6 Nov, 2021, https://scitok.com/project/p29d6a91f
Joshua Galanter. "Genome-wide methylation data mirror ancestry information" Scitok. (Nov 6, 2021). https://scitok.com/project/p/29d6a91f
Joshua Galanter (Nov 6, 2021). Genome-wide methylation data mirror ancestry information Scitok. https://scitok.com/project/p/29d6a91f
Joshua Galanter. Genome-wide methylation data mirror ancestry information[video]. 2021 Nov 6. https://scitok.com/project/p/29d6a91f
@online{al2006link, title={ Genome-wide methylation data mirror ancestry information }, author={ Galanter, Joshua }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/29d6a91f}, }