Author(s)
Carole Henry
Published 5 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Patrick Wilson
Published 13 Projects
Infectious Diseases Broadly Neutralizing Antibodies Universal Vaccine Hemagglutinin Stalk Immunology
Content
Antibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly-reactive because their footprints are typically large and extend to nearby variable HA residues. Here, we identified several human H3N2 HA RBS-targeting monoclonal antibodies (mAbs) that were sensitive to substitutions in conventional antigenic sites and were not broadly-reactive. However, we also identified one H3N2 HA RBS-targeting mAb that was exceptionally broadly reactive despite being sensitive to substitutions in residues outside of the RBS. We determined that similar antibodies are present at measurable levels in the sera of some individuals but that they are inefficiently elicited by conventional vaccines. Our data indicate that some HA RBS-targeting antibodies can be surprisingly effective against variable viral strains even if they are somewhat sensitive to substitutions in HA residues adjacent to the RBS.
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Patrick Wilson. (2021, Oct 29).Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans[Video]. Scitok. https://scitok.com/project/p/2cd2650d
J. Zost Seth. "Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans" Scitok, uploaded by Wilson Patrick, 29 Oct, 2021, https://scitok.com/project/p2cd2650d
Patrick Wilson. "Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans" Scitok. (Oct 29, 2021). https://scitok.com/project/p/2cd2650d
Patrick Wilson (Oct 29, 2021). Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans Scitok. https://scitok.com/project/p/2cd2650d
Patrick Wilson. Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans[video]. 2021 Oct 29. https://scitok.com/project/p/2cd2650d
@online{al2006link, title={ Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans }, author={ Wilson, Patrick }, organization={Scitok}, month={ Oct }, day={ 29 }, year={ 2021 }, url = {https://scitok.com/project/p/2cd2650d}, }