High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays

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Author Name


Loren Frank

Professor at University of California, San Francisco

Field of Study: Biology , Published 30 Projects

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Published in Neuron, Jan 2019


•  Modular polymer electrode-based system capable of recording up to 1,024 channels

  • Recording from 375 single units across multiple regions in freely behaving rats
    •  Single-unit recording longevity for 160 or more days post-implantation
  • System capable of tracking populations of single units continuously for over a week


    The brain is a massive neuronal network, organized into anatomically distributed sub-circuits, with functionally relevant activity occurring at timescales ranging from milliseconds to years. Current methods to monitor neural activity, however, lack the necessary conjunction of anatomical spatial coverage, temporal resolution, and long-term stability to measure this distributed activity. Here we introduce a large-scale, multi-site, extracellular recording platform that integrates polymer electrodes with a modular stacking headstage design supporting up to 1,024 recording channels in freely behaving rats. This system can support months-long recordings from hundreds of well-isolated units across multiple brain regions. Moreover, these recordings are stable enough to track large numbers of single units for over a week. This platform enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale evolution of anatomically distributed circuits, and thereby provides a new tool for understanding brain activity.

Brain 5 Projects
Neural Activitiy
Neural Activitiy 1 Project
Brain Recording
Brain Recording 2 Projects
Distributed Brain
Distributed Brain 1 Project
Neuroscience 179 Projects