Author(s)
Andre Franke
Published 4 Projects
Neuroscience Hippocampus Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd)
Yunpeng Wang
Published 23 Projects
First Episode Genetics Diffusivity Sleep Polygenic Risk Score
Content
Video Abstract (AI generated) (01:06) Paper PreprintINTRODUCTION: It is unknown whether genetic risk for Alzheimer`s disease (AD) represents a stable influence on the brain from early in life, or whether effects are age-dependent. It is critical to characterize the effects of genetic risk factors on the primary neural substrate of AD, the hippocampus, throughout life. METHODS: Relations of polygenic risk score (PGS) for AD, including variants in Apolipoprotein E (APOE) with hippocampal volume and its change were assessed in a healthy longitudinal lifespan sample (n = 1181, 4-95 years), followed for up to 11 years with a total of 2690 MRI scans. RESULTS: AD-PGS showed a significant negative effect on hippocampal volume. Offset effects of AD-PGS and APOE ϵ4 were present in hippocampal development, and interactions between age and genetic risk on volume change were not consistently observed. DISCUSSION: Endophenotypic manifestation of polygenic risk for AD may be seen across the lifespan in healthy persons.
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Yunpeng Wang. (2021, Oct 28).Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan[Video]. Scitok. https://scitok.com/project/p/3461b6fd
B. Walhovd Kristine. "Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan" Scitok, uploaded by Wang Yunpeng, 28 Oct, 2021, https://scitok.com/project/p3461b6fd
Yunpeng Wang. "Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan" Scitok. (Oct 28, 2021). https://scitok.com/project/p/3461b6fd
Yunpeng Wang (Oct 28, 2021). Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan Scitok. https://scitok.com/project/p/3461b6fd
Yunpeng Wang. Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan[video]. 2021 Oct 28. https://scitok.com/project/p/3461b6fd
@online{al2006link, title={ Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan }, author={ Wang, Yunpeng }, organization={Scitok}, month={ Oct }, day={ 28 }, year={ 2021 }, url = {https://scitok.com/project/p/3461b6fd}, }