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Video Abstract (AI generated) (01:40) Paper Preprint Journal of Biological ChemistryFerroptosis is an iron-dependent programmed cell death resulting from alterations of metabolic processes. However, its regulation and physiological significance remain to be elucidated. By analyzing transcriptional responses of murine embryonic fibroblasts exposed to the ferroptosis-inducer erastin, we found that a set of genes related to oxidative stress protection was induced upon ferroptosis. We further showed that the transcription factor BACH1 promoted ferroptosis by repressing the expression of a subset of erastin-inducible genes involved in the synthesis of glutathione or metabolism of intracellular labile iron, including Gclm, Gclc, Slc7a11, Hmox1, Fth1, Ftl1, and Slc40a1. Compared with wild-type mice, Bach1-/- mice showed resistance to myocardial infarction, the seriousness of which was palliated by the iron-chelator deferasirox, which suppressed ferroptosis. Our findings suggest that ferroptosis is programmed at the transcriptional level to induce genes combating labile-iron-induced oxidative stress and executed upon disruption of the balance between the transcriptional induction of protective genes and accumulation of iron-mediated damage. BACH1 is suggested to control the threshold of ferroptosis and to be a therapeutic target for palliating myocardial infarction.
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Hironari Nishizawa. (2021, Nov 5).Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1[Video]. Scitok. https://scitok.com/project/p/34ce2a25
Nishizawa Hironari. "Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1" Scitok, uploaded by Nishizawa Hironari, 5 Nov, 2021, https://scitok.com/project/p34ce2a25
Hironari Nishizawa. "Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1" Scitok. (Nov 5, 2021). https://scitok.com/project/p/34ce2a25
Hironari Nishizawa (Nov 5, 2021). Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1 Scitok. https://scitok.com/project/p/34ce2a25
Hironari Nishizawa. Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1[video]. 2021 Nov 5. https://scitok.com/project/p/34ce2a25
@online{al2006link, title={ Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1 }, author={ Nishizawa, Hironari }, organization={Scitok}, month={ Nov }, day={ 5 }, year={ 2021 }, url = {https://scitok.com/project/p/34ce2a25}, }