Author(s)
Gabrielle Boucher
Published 2 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Dermot P.B. McGovern
Published 3 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Talin Haritunians
Published 3 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Michiaki Kubo
Published 2 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Subra Kugathasan
Published 2 Projects
Infectious Diseases Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Soumya Raychaudhuri
Published 2 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Stefan Schreiber
Published 3 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Atsushi Takahashi
Published 3 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Behrooz Z. Alizadeh
Published 5 Projects
genomics Neuroscience Genetics Genetic And Genomic Medicine Schizophrenia
Rinse K. Weersma
Published 3 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
John D Rioux
Published 3 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Steven R Brant
Published 2 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Content
Video Abstract (AI generated) (01:50) Paper PreprintInflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD, and specifically DRB1*01:03 as a determining factor for ulcerative colitis (UC). However, for most of the association signal such a delineation could not be made due to tight structures of linkage disequilibrium within the HLA. The aim of this study was therefore to further characterize the HLA signal using a trans-ethnic approach. We performed a comprehensive fine mapping of single HLA alleles in UC in a cohort of 9,272 individuals with African American, East Asian, Puerto Rican, Indian and Iranian descent and 40,691 previously analyzed Caucasians, additionally analyzing whole HLA haplotypes. We computationally characterized the binding of associated HLA alleles to human self-peptides and analysed the physico-chemical properties of the HLA proteins and predicted self-peptidomes. Highlighting alleles of the HLA-DRB1*15 group and their correlated HLA-DQ-DR haplotypes, we identified consistent associations across different ethnicities but also identified population-specific signals. We observed that DRB1*01:03 is mostly present in individuals of Western European descent and hardly present in non-Caucasian individuals. We found peptides predicted to bind to risk HLA alleles to be rich in positively charged amino acids such. We conclude that the HLA plays an important role for UC susceptibility across different ethnicities. This research further implicates specific features of peptides that are predicted to bind risk and protective HLA proteins.
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Behrooz Z. Alizadeh. (2021, Oct 27).Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations[Video]. Scitok. https://scitok.com/project/p/3ae11768
Degenhardt Frauke. "Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations" Scitok, uploaded by Z. Alizadeh Behrooz, 27 Oct, 2021, https://scitok.com/project/p3ae11768
Behrooz Z. Alizadeh. "Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations" Scitok. (Oct 27, 2021). https://scitok.com/project/p/3ae11768
Behrooz Z. Alizadeh (Oct 27, 2021). Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations Scitok. https://scitok.com/project/p/3ae11768
Behrooz Z. Alizadeh. Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations[video]. 2021 Oct 27. https://scitok.com/project/p/3ae11768
@online{al2006link, title={ Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations }, author={ Z. Alizadeh, Behrooz }, organization={Scitok}, month={ Oct }, day={ 27 }, year={ 2021 }, url = {https://scitok.com/project/p/3ae11768}, }