Author(s)
Jenna J. Guthmiller
Published 6 Projects
Immunology Microbiology Infectious Diseases Influenza Hemagglutinin Stalk
Henry A. Utset
Published 2 Projects
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Carole Henry
Published 5 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Nai-Ying Zheng
Published 4 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Min Huang
Published 5 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Peter Palese
Published 4 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Content
Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess differential glycosylation patterns than viruses circulating amongst humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived sulfated N-acetyllactosamine (LacNAc) that is an antigenic decoy. Half of subjects that received an egg-grown vaccine mounted an antibody response against this egg-derived antigen. Egg-binding monoclonal antibodies specifically bind viruses grown in eggs, but not viruses grown in other chicken derived cells, suggesting only egg-grown vaccines can induce anti-LacNAc antibodies. Notably, antibodies against the sulfated LacNAc utilized a restricted antibody repertoire and possessed features of natural antibodies, as most antibodies were IgM and have simple heavy chain complementarity determining region 3. By analyzing a public dataset of influenza virus vaccine induced plasmablasts, we discovered egg-binding public clonotypes that were shared across studies. Together, this study shows that egg-grown vaccines can induce antibodies against an egg-associated glycan, which may divert the host immune response away from protective epitopes.
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Patrick Wilson. (2021, Oct 29).An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines[Video]. Scitok. https://scitok.com/project/p/4060b724
J. Guthmiller Jenna. "An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines" Scitok, uploaded by Wilson Patrick, 29 Oct, 2021, https://scitok.com/project/p4060b724
Patrick Wilson. "An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines" Scitok. (Oct 29, 2021). https://scitok.com/project/p/4060b724
Patrick Wilson (Oct 29, 2021). An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines Scitok. https://scitok.com/project/p/4060b724
Patrick Wilson. An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines[video]. 2021 Oct 29. https://scitok.com/project/p/4060b724
@online{al2006link, title={ An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines }, author={ Wilson, Patrick }, organization={Scitok}, month={ Oct }, day={ 29 }, year={ 2021 }, url = {https://scitok.com/project/p/4060b724}, }