Author(s)
Giovanni Volpe
Published 5 Projects
Neuroscience Introduction Development Cell Environment Interaction Active Matter
Content
Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau protein in neurons is one of the hallmarks of AD and has been connected to the loss of dendritic spines of pyramidal cells, which are the major targets of cortical excitatory synapses and key elements in memory storage. However, the detailed mechanisms underlying the loss of dendritic spines in patients with AD are still unclear. Here, comparing dendrites with and without tau pathology of AD patients, we show that the presence of tau pathology determines the loss of dendritic spines in blocks, ruling out alternative models where spine loss occurs randomly. Since memory storage has been associated with synaptic clusters, the present results provide a new insight into the mechanisms by which tau drives synaptic damage in AD, paving the way to memory deficits by altering spine organization. ### Competing Interest Statement The authors have declared no competing interest.
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Giovanni Volpe. (2021, Oct 30).Dendritic spines are lost in clusters in patients with Alzheimers disease[Video]. Scitok. https://scitok.com/project/p/45ebe028
Mijalkov Mite. "Dendritic spines are lost in clusters in patients with Alzheimers disease" Scitok, uploaded by Volpe Giovanni, 30 Oct, 2021, https://scitok.com/project/p45ebe028
Giovanni Volpe. "Dendritic spines are lost in clusters in patients with Alzheimers disease" Scitok. (Oct 30, 2021). https://scitok.com/project/p/45ebe028
Giovanni Volpe (Oct 30, 2021). Dendritic spines are lost in clusters in patients with Alzheimers disease Scitok. https://scitok.com/project/p/45ebe028
Giovanni Volpe. Dendritic spines are lost in clusters in patients with Alzheimers disease[video]. 2021 Oct 30. https://scitok.com/project/p/45ebe028
@online{al2006link, title={ Dendritic spines are lost in clusters in patients with Alzheimers disease }, author={ Volpe, Giovanni }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/45ebe028}, }