Author(s)
Content
Video Abstract (AI generated) (01:09) Paper Preprint Supllemental figures MethodsDisinhibition is an obligatory initial step in the remodeling of cortical circuits by sensory experience, yet the underlying mechanisms remain unclear. Our investigation of mechanisms for disinhibition in the classical model of ocular dominance plasticity (ODP) uncovered an unexpected novel form of experience-dependent circuit plasticity. In layer 2/3 of mouse visual cortex monocular deprivation triggers an "all-or-none" elimination of approximately half the connections from local pyramidal cells onto parvalbumin-positive interneurons (Pyr[->]PV), without affecting the strength of the remaining connections. This loss of Pyr[->]PV connections is transient, lasting one day only, has a critical period commensurate with the ODP critical period, and is contingent on a reduction of neuropentraxin2 (NPTX2), which normally stabilizes Pyr[->]PV connections. Bidirectional manipulations of NPTX2 functionality that prevent/promote the elimination Pyr[->]PV connections also promote/prevent ODP. We surmise, therefore, that this rapid and reversible loss of local Pyr[->]PV circuitry gates experience-dependent cortical plasticity.
More Projects
Loren Frank
13 views • 2 years ago
Global Immunotalks
390 views • 3 years ago
Laurel Yohe
2 views • 2 years ago
Global Immunotalks
130 views • 3 years ago
Jignesh H. Parmar
0 views • 2 years ago
Winston A. Haynes
0 views • 2 years ago
Noam Mazor
0 views • 2 years ago
Global Immunotalks
182 views • 3 years ago
Cem Yuksel
345 views • 3 years ago
Oscar Gonzalez-Recio
3 views • 2 years ago
Please pick a style:
Alfredo Kirkwood. (2021, Oct 31).All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity[Video]. Scitok. https://scitok.com/project/p/4a7abd9e
Severin Daniel. "All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity" Scitok, uploaded by Kirkwood Alfredo, 31 Oct, 2021, https://scitok.com/project/p4a7abd9e
Alfredo Kirkwood. "All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity" Scitok. (Oct 31, 2021). https://scitok.com/project/p/4a7abd9e
Alfredo Kirkwood (Oct 31, 2021). All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity Scitok. https://scitok.com/project/p/4a7abd9e
Alfredo Kirkwood. All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity[video]. 2021 Oct 31. https://scitok.com/project/p/4a7abd9e
@online{al2006link, title={ All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity }, author={ Kirkwood, Alfredo }, organization={Scitok}, month={ Oct }, day={ 31 }, year={ 2021 }, url = {https://scitok.com/project/p/4a7abd9e}, }