This is recorded as part of the UCSF Mission in a Minute series. Loren Frank, PhD, is an associate professor in the UCSF Department of Physiology. He is interested in the brain's ability to store experiences and then use them to guide behavior. His goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. In particular, his laboratory focuses on the circuitry of the hippocampus and anatomically related regions. He and his colleagues use a combination of techniques, including large scale multielectrode recording, targeted optogenetic interventions and behavioral manipulations of awake, behaving animals to understand how the brain learns and remembers.