Author(s)
Jeroen R. Huyghe
Published 1 Project
Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Tabitha A Harrison
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Stephanie A Bien
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Heather Hampel
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Jane C. Figueiredo
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Stephanie L. Schmit
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
David V Conti
Published 1 Project
Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Sai Chen
Published 2 Projects
Genetics Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity
Conghui Qu
Published 1 Project
Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Yi Lin
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Richard Barfield
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
John A. Baron
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Amanda J. Cross
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Brenda Diergaarde
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
David Duggan
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Sophia Harlid
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Liher Imaz
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Hyun Min Kang
Published 5 Projects
genomics Genetics Genetic And Genomic Medicine Distal Genetic Risk Factors
David M Levine
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Vittorio Perduca
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Aurora Perez-Cornago
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Lori C. Sakoda
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Fredrick R. Schumacher
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Martha L. Slattery
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Amanda E. Toland
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Franzel JB van Duijnhoven
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Bethany Van Guelpen
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Volker Arndt
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Antonio Agudo
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Demetrius Albanes
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
M Henar Alonso
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Kristin Anderson
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Coral Arnau-Collell
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Barbara Banbury
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Michael C Bassik
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Sonja I. Berndt
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Stéphane Bézieau
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Genetics Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity
D. Timothy Bishop
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Juergen Boehm
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Heiner Boeing
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Marie-Christine Boutron-Ruault
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Hermann Brenner
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genomics Genetics Genetic And Genomic Medicine Distal Genetic Risk Factors
Stefanie Brezina
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Stephan Buch
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Daniel D Buchanan
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Andrea Burnett-Hartman
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Bette J Caan
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Peter T. Campbell
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Prudence Carr
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Antoni Castells
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Sergi Castellví-Bel
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Andrew T. Chan
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Jenny Chang-Claude
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Stephen J. Chanock
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genomics Genetic And Genomic Medicine Sexual And Reproductive Health Distal Genetic Risk Factors
Keith R Curtis
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Albert de la Chapelle
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Douglas F. Easton
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genomics Genetics Genetic And Genomic Medicine Sexual And Reproductive Health Distal
Dallas R English
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Edith J.M. Feskens
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Manish Gala
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Steven J. Gallinger
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W. James Gauderman
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Graham G Giles
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genomics Genetic And Genomic Medicine Sexual And Reproductive Health Distal Genetic Risk Factors
Phyllis J Goodman
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William M Grady
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John S Grove
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Andrea Gsur
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Marc J Gunter
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Robert W. Haile
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Jochen Hampe
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Michael Hoffmeister
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John L Hopper
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Wan-Ling Hsu
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Wen-Yi Huang
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Thomas J. Hudson
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Mazda Jenab
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Mark A. Jenkins
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Amit D. Joshi
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Temitope O Keku
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Charles Kooperberg
Published 10 Projects
genomics Genetics Genetic And Genomic Medicine Sexual And Reproductive Health Distal
Tilman Kuhn
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Sébastien Küry
Published 4 Projects
Genetics Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity
Flavio Lejbkowicz
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Christopher I. Li
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Li Li
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Wolfgang Lieb
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Noralane M. Lindor
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Satu Männistö
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Sanford D Markowitz
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Roger L. Milne
Published 3 Projects
genomics Genetic And Genomic Medicine Sexual And Reproductive Health Distal Genetic Risk Factors
Lorena Moreno
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Neil Murphy
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Rami Nassir
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Kenneth Offit
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Shuji Ogino
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Salvatore Panico
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Patrick S Parfrey
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Rachel Pearlman
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Paul Pharoah
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Amanda I. Phipps
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Elizabeth A. Platz
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John D. Potter
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Ross L Prentice
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Lihong Qi
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Leon Raskin
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Elio Riboli
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Clemens Schafmayer
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Robert E. Schoen
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Daniela Seminara
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Mingyang Song
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Yu-Ru Su
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Catherine M. Tangen
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Stephen N Thibodeau
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Duncan C. Thomas
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Antonia Trichopolou
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Cornelia M. Ulrich
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Kala Visvanathan
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Pavel Vodicka
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Ludmila Vodickova
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Veronika Vymetalkova
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Korbinian Weigl
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Stephanie J Weinstein
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Emily White
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Michael O Woods
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Anna H. Wu
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Gonçalo R. Abecasis
Published 3 Projects
genomics Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity
Deborah A Nickerson
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genomics Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity
Peter C. Scacheri
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Anshul Kundaje
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Genetics Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity
Graham Casey
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Stephen B. Gruber
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Li Hsu
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Victor Moreno
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Richard B Hayes
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Genetic And Genomic Medicine Distal Genetic Risk Factors Genetic Heterogeneity Proximal Colon
Content
Video Abstract (AI generated) (02:12) Paper PreprintObjective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for sporadic CRC differs by anatomical subsite of the primary tumor has not been examined. Design To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48,214 CRC cases and 64,159 controls of European ancestry. We characterized effect heterogeneity at CRC risk loci using multinomial modeling. Results We identified 13 loci that reached genome-wide significance (P<5x10-8) and that were not reported by previous GWAS for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer. Conclusion Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumor.
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Sébastien Küry. (2021, Nov 4).Genetic architectures of proximal and distal colorectal cancer are partly distinct[Video]. Scitok. https://scitok.com/project/p/5a45a8c9
R. Huyghe Jeroen. "Genetic architectures of proximal and distal colorectal cancer are partly distinct" Scitok, uploaded by Küry Sébastien, 4 Nov, 2021, https://scitok.com/project/p5a45a8c9
Sébastien Küry. "Genetic architectures of proximal and distal colorectal cancer are partly distinct" Scitok. (Nov 4, 2021). https://scitok.com/project/p/5a45a8c9
Sébastien Küry (Nov 4, 2021). Genetic architectures of proximal and distal colorectal cancer are partly distinct Scitok. https://scitok.com/project/p/5a45a8c9
Sébastien Küry. Genetic architectures of proximal and distal colorectal cancer are partly distinct[video]. 2021 Nov 4. https://scitok.com/project/p/5a45a8c9
@online{al2006link, title={ Genetic architectures of proximal and distal colorectal cancer are partly distinct }, author={ Küry, Sébastien }, organization={Scitok}, month={ Nov }, day={ 4 }, year={ 2021 }, url = {https://scitok.com/project/p/5a45a8c9}, }