Author(s)
Kirstie J. Whitaker
Published 7 Projects
Neuroscience Structure 1. Introduction Gene Expression Schizophrenia
Sarah E Morgan
Published 5 Projects
Neuroscience Psychiatry And Clinical Psychology Natural Language Processing Schizophrenia Psychosis
Raymond J. Dolan
Published 5 Projects
Neuroscience 1. Introduction Gene Expression Schizophrenia Mri
John Suckling
Published 1 Project
Neuroscience Schizophrenia Development Allen Human Brain Atlas Fast Spiking Gabaergic Interneurons
the NSPN Consortium
Published 5 Projects
Neuroscience 1. Introduction Gene Expression Schizophrenia Mri
Petra E Vértes
Published 13 Projects
Neuroscience Psychiatry And Clinical Psychology Structure 1. Introduction Natural Language Processing
Edward T. Bullmore
Published 11 Projects
Neuroscience Structure 1. Introduction Gene Expression Schizophrenia
Content
Background Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits but the underlying changes in brain structure that mechanistically link genomic variation to schizotypal experience and behaviour are unclear. Methods We assessed schizotypy using a self-reported questionnaire, and measured magnetization transfer (MT), as a putative micro-structural MRI marker of intra-cortical myelination, in 68 brain regions, in 248 healthy young people (aged 14-25 years). We used normative adult brain gene expression data, and partial least squares (PLS) analysis, to find the weighted gene expression pattern that was most co-located with the cortical map of schizotypy-related magnetization (SRM). Results Magnetization was significantly correlated with schizotypy in bilateral posterior cingulate cortex and precuneus (and for disorganized schizotypy also in medial prefrontal cortex; all FDR-corrected P < 0.05), which are regions of the default mode network specialized for social and memory functions. The genes most positively weighted on the whole genome expression map co-located with SRM were enriched for genes that were significantly down-regulated in two prior case-control histological studies of brain gene expression in schizophrenia. Conversely, the most negatively weighted genes were enriched for genes that were transcriptionally up-regulated in schizophrenia. Positively weighted (down-regulated) genes were enriched for neuronal, specifically inter-neuronal, affiliations and coded a network of proteins comprising a few highly interactive “hubs” such as parvalbumin and calmodulin. Conclusions Microstructural MRI maps of intracortical magnetization can be linked to both the behavioural traits of schizotypy and to prior histological data on dysregulated gene expression in schizophrenia.
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Petra E Vértes. (2021, Nov 9).Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes[Video]. Scitok. https://scitok.com/project/p/5bdb2e70
Romero-Garcia Rafael. "Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes" Scitok, uploaded by E Vértes Petra, 9 Nov, 2021, https://scitok.com/project/p5bdb2e70
Petra E Vértes. "Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes" Scitok. (Nov 9, 2021). https://scitok.com/project/p/5bdb2e70
Petra E Vértes (Nov 9, 2021). Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes Scitok. https://scitok.com/project/p/5bdb2e70
Petra E Vértes. Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes[video]. 2021 Nov 9. https://scitok.com/project/p/5bdb2e70
@online{al2006link, title={ Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes }, author={ E Vértes, Petra }, organization={Scitok}, month={ Nov }, day={ 9 }, year={ 2021 }, url = {https://scitok.com/project/p/5bdb2e70}, }