Author(s)
Tesfa Dejenie Habtewold
Published 3 Projects
Epidemiology Neuroscience Key Words Schizophrenia Meta Analysis
Lyan H. Rodijk
Published 1 Project
Neuroscience Schizophrenia Systematic Review Psychosis Growth Mixture Modelling
Edith J. Liemburg
Published 1 Project
Neuroscience Schizophrenia Systematic Review Psychosis Growth Mixture Modelling
Grigory Sidorenkov
Published 1 Project
Neuroscience Schizophrenia Systematic Review Psychosis Growth Mixture Modelling
H. Marike Boezen
Published 1 Project
Neuroscience Schizophrenia Systematic Review Psychosis Growth Mixture Modelling
Richard Bruggeman
Published 3 Projects
genomics Neuroscience Genetics Schizophrenia Systematic Review
Content
Introduction To tackle the phenotypic heterogeneity of schizophrenia, data-driven methods are often applied to identify subtypes of its (sub)clinical symptoms though there is no systematic review. Aims To summarize the evidence from cluster- and trajectory-based studies of positive, negative and cognitive symptoms in patients with schizophrenia spectrum disorders, their siblings and healthy people. Additionally, we aimed to highlight knowledge gaps and point out future directions to optimize the translatability of cluster- and trajectory-based studies. Methods A systematic review was performed through searching PsycINFO, PubMed, PsycTESTS, PsycARTICLES, SCOPUS, EMBASE, and Web of Science electronic databases. Both cross-sectional and longitudinal studies published from 2008 to 2019, which reported at least two statistically derived clusters or trajectories were included. Two reviewers independently screened and extracted the data. Results Of 2,285 studies retrieved, 50 studies (17 longitudinal and 33 cross-sectional) conducted in 30 countries were selected for review. Longitudinal studies discovered two to five trajectories of positive and negative symptoms in patient, and four to five trajectories of cognitive deficits in patient and sibling. In cross-sectional studies, three clusters of positive and negative symptoms in patient, four clusters of positive and negative schizotypy in sibling, and three to five clusters of cognitive deficits in patient and sibling were identified. These studies also reported multidimensional predictors of clusters and trajectories. Conclusions Our findings indicate that (sub)clinical symptoms of schizophrenia are more heterogeneous than currently recognized. Identified clusters and trajectories can be used as a basis for personalized psychiatry.
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Behrooz Z. Alizadeh. (2021, Oct 27).Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies[Video]. Scitok. https://scitok.com/project/p/603fe1a9
Dejenie Habtewold Tesfa. "Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies" Scitok, uploaded by Z. Alizadeh Behrooz, 27 Oct, 2021, https://scitok.com/project/p603fe1a9
Behrooz Z. Alizadeh. "Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies" Scitok. (Oct 27, 2021). https://scitok.com/project/p/603fe1a9
Behrooz Z. Alizadeh (Oct 27, 2021). Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies Scitok. https://scitok.com/project/p/603fe1a9
Behrooz Z. Alizadeh. Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies[video]. 2021 Oct 27. https://scitok.com/project/p/603fe1a9
@online{al2006link, title={ Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies }, author={ Z. Alizadeh, Behrooz }, organization={Scitok}, month={ Oct }, day={ 27 }, year={ 2021 }, url = {https://scitok.com/project/p/603fe1a9}, }