Author(s)
Jiandong Zhou
Published 16 Projects
Infectious Diseases Heart Failure Cardiovascular Medicine Risk Stratification Frailty Score
Gary Tse
Professor and Principal Investigator at Tianjin Medical University | TIJMU · Tianjin Institute of Cardiology
Published 11 Projects
COVID-19 Arrhythmia Hypokalaemia Ventricular Arrhythmogenesis Afterdepolarization
Sharen Lee
Published 16 Projects
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Wing Tak Wong
Published 8 Projects
COVID-19 Infectious Diseases Key Words Cardiovascular Medicine Angiotensin Receptor Blockers
Xingsong Wang
Published 1 Project
COVID-19 Infectious Diseases Key Words Angiotensin Receptor Blockers Mortality
William KK Wu
Published 6 Projects
COVID-19 Infectious Diseases Key Words Cardiovascular Medicine Angiotensin Receptor Blockers
Tong Liu
Published 16 Projects
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Zhidong Cao
Published 3 Projects
COVID-19 Infectious Diseases Key Words Angiotensin Receptor Blockers Mortality
Dajun Zeng
Published 3 Projects
COVID-19 Infectious Diseases Key Words Angiotensin Receptor Blockers Mortality
Bernard Man Yung Cheung
Published 23 Projects
Infectious Diseases Heart Failure Cardiovascular Medicine Frailty Score COVID-19
Content
Video Abstract (AI generated) (02:57) Paper PreprintAimsRenin-angiotensin system blockers such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of adverse outcomes in COVID-19. In this study, the relationships between ACEI/ARB use and COVID-19 related mortality were examined. MethodsConsecutive patients diagnosed with COVID-19 by RT-PCR at the Hong Kong Hospital Authority between 1st January and 28th July 2020 were included. ResultsThis study included 2774 patients. The mortality rate of the COVID-19 positive group was 1.5% (n=42). Those who died had a higher median age (82.3[76.5-89.5] vs. 42.9[28.2-59.5] years old; P<0.0001), more likely to have baseline comorbidities of cardiovascular disease, diabetes mellitus, hypertension, and chronic kidney disease (P<0.0001). They were more frequently prescribed ACEI/ARBs at baseline, and steroids, lopinavir/ritonavir, ribavirin and hydroxychloroquine during admission (P<0.0001). They also had a higher white cell count, higher neutrophil count, lower platelet count, prolonged prothrombin time and activated partial thromboplastin time, higher D-dimer, troponin, lactate dehydrogenase, creatinine, alanine transaminase, aspartate transaminase and alkaline phosphatase (P<0.0001). Multivariate Cox regression showed that age, cardiovascular disease, renal disease, diabetes mellitus, the use of ACEIs/ARBs and diuretics, and various laboratory tests remained significant predictors of mortality. ConclusionsWe report that an association between ACEIs/ARBs with COVID-19 related mortality even after adjusting for cardiovascular and other comorbidities, as well as medication use. Patients with greater comorbidity burden and laboratory markers reflecting deranged clotting, renal and liver function, and increased tissue inflammation, and ACEI/ARB use have a higher mortality risk. Key PointsO_LIWe report that an association between ACEIs/ARBs with COVID-19 related mortality even after adjusting for cardiovascular and other comorbidities, as well as medication use. C_LIO_LIPatients with greater comorbidity burden and laboratory markers reflecting deranged clotting, renal and liver function, and increased tissue inflammation, and ACEI/ARB use have a higher mortality risk. C_LI
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Gary Tse. (2021, Nov 8).Renin-angiotensin system blockers and mortality in COVID-19: a territory-wide study from Hong Kong[Video]. Scitok. https://scitok.com/project/p/72ec33e9
Zhou Jiandong. "Renin-angiotensin system blockers and mortality in COVID-19: a territory-wide study from Hong Kong" Scitok, uploaded by Tse Gary, 8 Nov, 2021, https://scitok.com/project/p72ec33e9
Gary Tse. "Renin-angiotensin system blockers and mortality in COVID-19: a territory-wide study from Hong Kong" Scitok. (Nov 8, 2021). https://scitok.com/project/p/72ec33e9
Gary Tse (Nov 8, 2021). Renin-angiotensin system blockers and mortality in COVID-19: a territory-wide study from Hong Kong Scitok. https://scitok.com/project/p/72ec33e9
Gary Tse. Renin-angiotensin system blockers and mortality in COVID-19: a territory-wide study from Hong Kong[video]. 2021 Nov 8. https://scitok.com/project/p/72ec33e9
@online{al2006link, title={ Renin-angiotensin system blockers and mortality in COVID-19: a territory-wide study from Hong Kong }, author={ Tse, Gary }, organization={Scitok}, month={ Nov }, day={ 8 }, year={ 2021 }, url = {https://scitok.com/project/p/72ec33e9}, }