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Video Abstract (AI generated) (01:34) Paper PreprintMany naturally-occurring bacteria lead a lifestyle of metabolic dependency, i.e., they depend on others for crucial resources. We do not understand what factors drive bacteria towards this lifestyle, and how. Here, we systematically show that horizontal gene transfer (HGT) plays a crucial role in the evolution of dependencies in bacteria. Across 835 bacterial species, we map gene gain-loss dynamics on a deep evolutionary tree, and assess the impact of HGT and gene loss on bacterial metabolic networks. Our analyses suggest that genes acquired by HGT can affect which genes are later lost. Dependency evolution is contingent on earlier HGT because of two reasons. First, we find that HGT typically adds new catabolic routes to bacterial metabolic networks. This increases the chance of new metabolic interactions between bacteria, which is a prerequisite for dependency evolution. Second, we show that gaining new routes can promote the loss of specific ancestral routes (a mechanism we call “coupled gains and losses”, CGLs). Phylogenetic patterns indicate that both types of dependencies — those mediated by CGLs and those purely by gene loss — are equally likely. Our results highlight HGT as an important driver of metabolic dependency evolution in bacteria.
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Akshit Goyal. (2021, Oct 30).Horizontal gene transfer drives the evolution of dependencies in bacteria[Video]. Scitok. https://scitok.com/project/p/7506230a
Goyal Akshit. "Horizontal gene transfer drives the evolution of dependencies in bacteria" Scitok, uploaded by Goyal Akshit, 30 Oct, 2021, https://scitok.com/project/p7506230a
Akshit Goyal. "Horizontal gene transfer drives the evolution of dependencies in bacteria" Scitok. (Oct 30, 2021). https://scitok.com/project/p/7506230a
Akshit Goyal (Oct 30, 2021). Horizontal gene transfer drives the evolution of dependencies in bacteria Scitok. https://scitok.com/project/p/7506230a
Akshit Goyal. Horizontal gene transfer drives the evolution of dependencies in bacteria[video]. 2021 Oct 30. https://scitok.com/project/p/7506230a
@online{al2006link, title={ Horizontal gene transfer drives the evolution of dependencies in bacteria }, author={ Goyal, Akshit }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/7506230a}, }