Differential gene expression in scrub typhus compared to other acute febrile infections by bioinformatic approaches

0 views • Nov 9, 2021


Author Name

Manisha Mandal

Add New Author

Scrub typhus (ST), caused with the infection of Orientia tsutsugamushi, without eschar, is a febrile illness that mimics malaria (ML), dengue (DG), and other rickettsioses such as murine typhus (MT). Comparative analysis of microarray gene expression profiles of GSE16463 dataset, from O. tsutsugamushi infected monocytes, was performed to identify transcriptional signatures in ST discriminated from other acute febrile infections, accompanied by functional pathways and enrichment analysis in disease pathogenesis. A unique 31 ST-associated signature genes obtained in this study could help distinguish ST from other febrile illnesses DG, ML and MT. The functional pathways significantly enriched in ST disease group included translocation of ZAP-70 to immunological synapse, and phosphorylation of CD3 and TCR zeta chains, involving PTPN22 and CD3G genes, which could further help in the understanding of molecular pathophysiology of ST and discovering novel drug targets as well as vaccine developments.

Gse16463 Dataset
Gse16463 Dataset 1 Project
Gene Expression
Gene Expression 6 Projects
Scrub Typhus
Scrub Typhus 1 Project
Orientia Tsutsugamushi
Orientia Tsutsugamushi 1 Project
Differential 1 Project
Infectious Diseases
Infectious Diseases 62 Projects