Author(s)
Daniel Stadlbauer
Published 9 Projects
COVID-19 Coronavirus SARS-CoV-2 Epidemiology Infectious Diseases
Kaijun Jiang
Published 5 Projects
Microbiology Epidemiology Infectious Diseases Allergy And Immunology
Fatima Amanat
Published 24 Projects
Infectious Diseases Epidemiology Allergy And Immunology Immunology Covid19
Content
Video Abstract (AI generated) (01:13) Paper PreprintHerein we measured CD4+ T cell responses against common cold corona (CCC) viruses and SARS-CoV-2 in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC reactive T cells in SARS-CoV-2 seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC reactivity was decreased in SARS-CoV-2 infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego.
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Florian Krammer. (2021, Oct 30).Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers[Video]. Scitok. https://scitok.com/project/p/80fcca79
da Silva Antunes Ricardo. "Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/p80fcca79
Florian Krammer. "Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers" Scitok. (Oct 30, 2021). https://scitok.com/project/p/80fcca79
Florian Krammer (Oct 30, 2021). Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers Scitok. https://scitok.com/project/p/80fcca79
Florian Krammer. Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers[video]. 2021 Oct 30. https://scitok.com/project/p/80fcca79
@online{al2006link, title={ Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/80fcca79}, }