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Video Abstract (AI generated) (01:30) Paper PreprintHuman hookworm Necator Americanus (NA) causes iron deficiency anemia, as the parasite ingests blood from the gastrointestinal tract of its human host. This bioinformatics-based study focuses on eight of the cathepsin B-like cysteine proteases (CPs) of the worm to explore their pathogenic potential. CP1 - CP6, which harbored the active site cysteine residue for enzymatic activity, were relevantly observed to have N-terminal signal peptide for extracellular localization. The secretory CPs could be releasing indigenous worm heparin at the host-pathogen interface for anticoagulation purposes. CP2 and CP3 showed a novel hemoglobinase motif that could be a prerequisite for hemoglobin degradation. CP1 and CP6 shared similar enzymatic-pocket features with cathepsin B and cruzain that cleave high molecular weight kininogen for blood-thinning activity. CP1, CP2, CP3, CP5 and CP6 were predicted to bind heparin, at their C terminal domain, like human cathepsin B and cruzain non-covalently bind heparin to enhance their activity. The actions of the NA CPs in concert with heparin, have implications for anti-heparin and heparin analog design against hookworm infection.
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Arpita Banerjee. (2021, Nov 5).Cysteine proteases of human hookworm Necator Americanus as virulence factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study[Video]. Scitok. https://scitok.com/project/p/83a0a065
Banerjee Arpita. "Cysteine proteases of human hookworm Necator Americanus as virulence factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study" Scitok, uploaded by Banerjee Arpita, 5 Nov, 2021, https://scitok.com/project/p83a0a065
Arpita Banerjee. "Cysteine proteases of human hookworm Necator Americanus as virulence factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study" Scitok. (Nov 5, 2021). https://scitok.com/project/p/83a0a065
Arpita Banerjee (Nov 5, 2021). Cysteine proteases of human hookworm Necator Americanus as virulence factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study Scitok. https://scitok.com/project/p/83a0a065
Arpita Banerjee. Cysteine proteases of human hookworm Necator Americanus as virulence factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study[video]. 2021 Nov 5. https://scitok.com/project/p/83a0a065
@online{al2006link, title={ Cysteine proteases of human hookworm Necator Americanus as virulence factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study }, author={ Banerjee, Arpita }, organization={Scitok}, month={ Nov }, day={ 5 }, year={ 2021 }, url = {https://scitok.com/project/p/83a0a065}, }