Author(s)
Ania Wajnberg
Published 4 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Damodara Rao Mendu
Published 5 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Suzanne Arinsburg
Published 3 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Melissa Gitman
Published 4 Projects
Infectious Diseases Key Words Influenza A Virus Next Nosocomial Outbreak
Viviana Simon
Published 15 Projects
Infectious Diseases Epidemiology Immunology Allergy And Immunology Nosocomial Outbreak
Carlos Cordon-Cardo
Published 5 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Content
Video Abstract (AI generated) (01:36) Paper PreprintBackground: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The percentage of infected individuals who seroconvert is still an open question. In addition, it has been shown in some individuals that viral genome can still be detected at considerable time post symptom resolution. Here we investigated both seroconversion and PCR-positivity in a large cohort of convalescent serum donors in New York City. Methods: Individuals with confirmed or suspected SARS-CoV-2 infection were screened via PCR for presence of viral genome and via enzyme-linked immunosorbent assay for presence of anti SARS-CoV-2 spike antibodies. Results: All but three confirmed SARS-CoV-2 patients seroconverted to the SARS-CoV-2 spike while only 37.4% of suspected SARS-CoV-2 patients seroconverted. PCR-positivity was detected up to 28 days from symptom resolution. Conclusions: Here we show that the vast majority of confirmed COVID19 patients seroconvert, potentially providing immunity to reinfection. We also report that in a large proportion of individuals, viral genome can be detected via PCR in the upper respiratory tract for weeks post symptom resolution, but it is unclear if this signal represents infectious virus.
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Florian Krammer. (2021, Oct 30).Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region[Video]. Scitok. https://scitok.com/project/p/87c5972b
Wajnberg Ania. "Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/p87c5972b
Florian Krammer. "Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region" Scitok. (Oct 30, 2021). https://scitok.com/project/p/87c5972b
Florian Krammer (Oct 30, 2021). Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region Scitok. https://scitok.com/project/p/87c5972b
Florian Krammer. Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region[video]. 2021 Oct 30. https://scitok.com/project/p/87c5972b
@online{al2006link, title={ Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/87c5972b}, }