Author(s)
Jenna J. Guthmiller
Published 6 Projects
Immunology Microbiology Infectious Diseases Influenza Hemagglutinin Stalk
Julianna Han
Published 1 Project
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Henry A. Utset
Published 2 Projects
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Linda Yu-Ling Lan
Published 2 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Carole Henry
Published 5 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Christopher T. Stamper
Published 3 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Olivia Stovicek
Published 4 Projects
Immunology Microbiology Infectious Diseases Influenza Hemagglutinin Stalk
Lauren E Gentles
Published 2 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Haley L. Dugan
Published 5 Projects
Immunology Microbiology Infectious Diseases Influenza Hemagglutinin Stalk
Nai-Ying Zheng
Published 4 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Sara T. Richey
Published 1 Project
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Micah E. Tepora
Published 1 Project
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Dalia J. Bitar
Published 1 Project
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Siriruk Changrob
Published 3 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Shirin Strohmeier
Published 9 Projects
Immunology Microbiology Infectious Diseases Allergy And Immunology Influenza
Min Huang
Published 5 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Adolfo García-Sastre
Published 1 Project
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Raffael Nachbagauer
Published 1 Project
Immunology Influenza Hemagglutinin Stalk Universal Vaccine Broadly Neutralizing Antibodies
Peter Palese
Published 4 Projects
Immunology Microbiology Influenza Hemagglutinin Stalk Universal Vaccine
Jesse D Bloom
Published 16 Projects
Infectious Diseases Antibodies Broadly Neutralizing Antibodies Universal Vaccine Hemagglutinin Stalk
Lynda Coughlan
Published 5 Projects
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Andrew B. Ward
Published 9 Projects
Immunology Microbiology Synthetic Biology Influenza Hemagglutinin Stalk
Content
Video Abstract (AI generated) (01:06) Paper Preprint Supplement Figures, Tables, and ReferencesBroadly neutralizing antibodies against influenza virus hemagglutinin (HA) have the potential to provide universal protection against influenza virus infections. Here, we report a distinct class of broadly neutralizing antibodies targeting an epitope toward the bottom of the HA stalk domain where HA is "anchored" to the viral membrane. Antibodies targeting this membrane-proximal anchor epitope utilized a highly restricted repertoire, which encode for two conserved motifs responsible for HA binding. Anchor targeting B cells were common in the human memory B cell repertoire across subjects, indicating pre-existing immunity against this epitope. Antibodies against the anchor epitope at both the serological and monoclonal antibody levels were potently induced in humans by a chimeric HA vaccine, a potential universal influenza virus vaccine. Altogether, this study reveals an underappreciated class of broadly neutralizing antibodies against H1-expressing viruses that can be robustly recalled by a candidate universal influenza virus vaccine.
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Patrick Wilson. (2021, Oct 29).A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin[Video]. Scitok. https://scitok.com/project/p/8bb7dfe8
J. Guthmiller Jenna. "A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin" Scitok, uploaded by Wilson Patrick, 29 Oct, 2021, https://scitok.com/project/p8bb7dfe8
Patrick Wilson. "A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin" Scitok. (Oct 29, 2021). https://scitok.com/project/p/8bb7dfe8
Patrick Wilson (Oct 29, 2021). A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin Scitok. https://scitok.com/project/p/8bb7dfe8
Patrick Wilson. A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin[video]. 2021 Oct 29. https://scitok.com/project/p/8bb7dfe8
@online{al2006link, title={ A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin }, author={ Wilson, Patrick }, organization={Scitok}, month={ Oct }, day={ 29 }, year={ 2021 }, url = {https://scitok.com/project/p/8bb7dfe8}, }