Author(s)
Fatima Amanat
Published 24 Projects
Infectious Diseases Epidemiology Allergy And Immunology Immunology Covid19
Content
Video Abstract (AI generated) (02:01) Paper PreprintSARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and economic disruptions. COVID-19 results in higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive coronavirus immunological responses, induced by circulating human coronaviruses, is critical to understand such divergent clinical outcomes. The cross-reactivity of coronavirus antibody responses of healthy children (n=89), adults (n=98), elderly (n=57), and COVID-19 patients (n=19) were analysed by systems serology. While moderate levels of cross-reactive SARS-CoV-2 IgG, IgM, and IgA were detected in healthy individuals, we identified serological signatures associated with SARS-CoV-2 antigen-specific Fc{gamma} receptor binding, which accurately distinguished COVID-19 patients from healthy individuals and suggested that SARS-CoV-2 induces qualitative changes to antibody Fc upon infection, enhancing Fc{gamma} receptor engagement. Vastly different serological signatures were observed between healthy children and elderly, with markedly higher cross-reactive SARS-CoV-2 IgA and IgG observed in elderly, whereas children displayed elevated SARS-CoV-2 IgM, including receptor binding domain-specific IgM with higher avidity. These results suggest that less-experienced humoral immunity associated with higher IgM, as observed in children, may have the potential to induce more potent antibodies upon SARS-CoV-2 infection. These key insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics.
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Florian Krammer. (2021, Oct 30).Distinct systems serology features in children, elderly and COVID patients[Video]. Scitok. https://scitok.com/project/p/8bc1c8b3
J. Selva Kevin. "Distinct systems serology features in children, elderly and COVID patients" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/p8bc1c8b3
Florian Krammer. "Distinct systems serology features in children, elderly and COVID patients" Scitok. (Oct 30, 2021). https://scitok.com/project/p/8bc1c8b3
Florian Krammer (Oct 30, 2021). Distinct systems serology features in children, elderly and COVID patients Scitok. https://scitok.com/project/p/8bc1c8b3
Florian Krammer. Distinct systems serology features in children, elderly and COVID patients[video]. 2021 Oct 30. https://scitok.com/project/p/8bc1c8b3
@online{al2006link, title={ Distinct systems serology features in children, elderly and COVID patients }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/8bc1c8b3}, }