Author(s)
Linda Archambault
Published 1 Project
Microbiology Biofilm Computational Modeling Agent Based Modeling Streptococcus Oralis
Sherli Koshy-Chenthittayil
Published 1 Project
Microbiology Biofilm Computational Modeling Agent Based Modeling Streptococcus Oralis
Angela Thompson
Published 1 Project
Microbiology Biofilm Computational Modeling Agent Based Modeling Streptococcus Oralis
Anna Dongari-Bagtzoglou
Published 1 Project
Microbiology Biofilm Computational Modeling Agent Based Modeling Streptococcus Oralis
Reinhard Laubenbacher
Published 2 Projects
Microbiology Homeostasis Pseudomonas Aeruginosa Biofilm Computational Modeling
Pedro Mendes
Published 8 Projects
Iron Metabolism Microbiology Cancer Biology Systems Biology Introduction
Content
Video Abstract (AI generated) (01:35) Paper PreprintAs common commensals residing on mucosal tissues, Lactobacillus species are known to encourage health, while recent findings highlight the pathogenic roles of Streptococcus species in these environments. In this study we used a combination of in vivo imaging experiments and computational modeling to explore biofilm interactions between Streptococcus oralis, an accessory pathogen in oral Candidiasis, and Lactobacillus paracasei, an organism with known probiotic properties. A computational agent-based model was created where the two species only interact by competing for space and nutrients. Quantification of bacterial growth in live biofilms indicated that S. oralis biomass and cell numbers were much lower than predicted by the model. Two subsequent models were then created to examine more complex interactions between these species, one where L. paracasei secretes a surfactant, and another where L. paracasei secretes an inhibitor of S. oralis growth. Further biofilm experiments support the hypothesis that L. paracasei may secrete an inhibitor of S. oralis growth, although they do not exclude that a surfactant could also be involved. This contribution shows how agent-based modeling and experiments can be used in synergy to address multiple species biofilm interactions, with important roles in mucosal health and disease.
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Pedro Mendes. (2021, Nov 5).Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling[Video]. Scitok. https://scitok.com/project/p/92535e61
Archambault Linda. "Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling" Scitok, uploaded by Mendes Pedro, 5 Nov, 2021, https://scitok.com/project/p92535e61
Pedro Mendes. "Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling" Scitok. (Nov 5, 2021). https://scitok.com/project/p/92535e61
Pedro Mendes (Nov 5, 2021). Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling Scitok. https://scitok.com/project/p/92535e61
Pedro Mendes. Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling[video]. 2021 Nov 5. https://scitok.com/project/p/92535e61
@online{al2006link, title={ Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling }, author={ Mendes, Pedro }, organization={Scitok}, month={ Nov }, day={ 5 }, year={ 2021 }, url = {https://scitok.com/project/p/92535e61}, }