Author(s)
Zhuoming Liu
Published 14 Projects
Infectious Diseases Cell Biology Inhibition COVID-19 Vacuolin 1
Sean P. J. Whelan
Published 14 Projects
Infectious Diseases Cell Biology Inhibition COVID-19 Vacuolin 1
Content
Video Abstract (AI generated) (01:19) Paper Preprint Supplemental Figures and TableWith the emergence of SARS-CoV-2 variants with increased transmissibility and potential resistance, antibodies and vaccines with broadly inhibitory activity are needed. Here we developed a panel of neutralizing anti-SARS-CoV-2 mAbs that bind the receptor binding domain of the spike protein at distinct epitopes and block virus attachment to cells and its receptor, human angiotensin converting enzyme-2 (hACE2). While several potently neutralizing mAbs protected K18-hACE2 transgenic mice against infection caused by historical SARS-CoV-2 strains, others induced escape variants in vivo and lost activity against emerging strains. We identified one mAb, SARS2-38, that potently neutralizes all SARS-CoV-2 variants of concern tested and protects mice against challenge by multiple SARS-CoV-2 strains. Structural analysis showed that SARS2-38 engages a conserved epitope proximal to the receptor binding motif. Thus, treatment with or induction of inhibitory antibodies that bind conserved spike epitopes may limit the loss of potency of therapies or vaccines against emerging SARS-CoV-2 variants.
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Zhuoming Liu. (2021, Nov 6).A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope[Video]. Scitok. https://scitok.com/project/p/926404ab
VanBlargan Laura. "A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope" Scitok, uploaded by Liu Zhuoming, 6 Nov, 2021, https://scitok.com/project/p926404ab
Zhuoming Liu. "A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope" Scitok. (Nov 6, 2021). https://scitok.com/project/p/926404ab
Zhuoming Liu (Nov 6, 2021). A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope Scitok. https://scitok.com/project/p/926404ab
Zhuoming Liu. A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope[video]. 2021 Nov 6. https://scitok.com/project/p/926404ab
@online{al2006link, title={ A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope }, author={ Liu, Zhuoming }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/926404ab}, }