Author(s)
Petra E VĂ©rtes
Published 13 Projects
Neuroscience Psychiatry And Clinical Psychology Structure 1. Introduction Natural Language Processing
Kirstie J. Whitaker
Published 7 Projects
Neuroscience Structure 1. Introduction Gene Expression Schizophrenia
Edward T. Bullmore
Published 11 Projects
Neuroscience Structure 1. Introduction Gene Expression Schizophrenia
Content
Video Abstract (AI generated) (01:38) Paper Preprint Cerebral CortexSeminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker sensitive to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8-85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of 7 cytoarchitectonic classes. From the first derivatives of these generally inverted-U trajectories, we defined three milestones: the age at peak growth; the age at onset of a stable plateau; and the age at the onset of decline. Age at peak growth had a bimodal distribution comprising an early (pre-pubertal) wave of primary sensory and motor cortices and a later (post-pubertal) wave of association, insular and limbic cortices. Most regions reached stability in the 30s but there was a second wave reaching stability in the 50s. Age at onset of decline was also bimodal: in some right hemisphere regions, the curve declined from the 60s, but in other left hemisphere regions, there was no significant decline from the stable plateau. Network analysis of the micro-structural connectome revealed that late developing (second wave) regions had significantly higher degree and other measures of centrality. These results are consistent with regionally heterogeneous waves of intracortical myelinogenesis and age-related demyelination, which may be relevant to the onset of neuropsychiatric disorders, and dementia, and the staged acquisition and decline of motor and cognitive skills over the course of the life-cycle.
More Projects
Loren Frank
13 views • 2 years ago
Global Immunotalks
390 views • 3 years ago
Laurel Yohe
2 views • 2 years ago
Global Immunotalks
130 views • 3 years ago
Jignesh H. Parmar
0 views • 2 years ago
Winston A. Haynes
0 views • 2 years ago
Noam Mazor
0 views • 2 years ago
Global Immunotalks
182 views • 3 years ago
Cem Yuksel
345 views • 2 years ago
Oscar Gonzalez-Recio
3 views • 2 years ago
Please pick a style:
Petra E VĂ©rtes. (2021, Nov 9).Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan[Video]. Scitok. https://scitok.com/project/p/9c9bf192
Grydeland HĂĄkon. "Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan" Scitok, uploaded by E VĂ©rtes Petra, 9 Nov, 2021, https://scitok.com/project/p9c9bf192
Petra E VĂ©rtes. "Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan" Scitok. (Nov 9, 2021). https://scitok.com/project/p/9c9bf192
Petra E VĂ©rtes (Nov 9, 2021). Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan Scitok. https://scitok.com/project/p/9c9bf192
Petra E VĂ©rtes. Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan[video]. 2021 Nov 9. https://scitok.com/project/p/9c9bf192
@online{al2006link, title={ Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan }, author={ E VĂ©rtes, Petra }, organization={Scitok}, month={ Nov }, day={ 9 }, year={ 2021 }, url = {https://scitok.com/project/p/9c9bf192}, }