Author(s)
Xueyong Zhu
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Andrew B. Ward
Published 9 Projects
Immunology Microbiology Synthetic Biology Influenza Hemagglutinin Stalk
Ian A. Wilson
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Content
Video Abstract (AI generated) (01:25) Paper PreprintCoronaviruses have caused several epidemics and pandemics including the ongoing coronavirus disease 2019 (COVID-19). Some prophylactic vaccines and therapeutic antibodies have already showed striking effectiveness against COVID-19. Nevertheless, concerns remain about antigenic drift in SARS-CoV-2 as well as threats from other sarbecoviruses. Cross-neutralizing antibodies to SARS-related viruses provide opportunities to address such concerns. Here, we report on crystal structures of a cross-neutralizing antibody CV38-142 in complex with the receptor binding domains from SARS-CoV-2 and SARS-CoV. Our structural findings provide mechanistic insights into how this antibody can accommodate antigenic variation in these viruses. CV38-142 synergizes with other cross-neutralizing antibodies, in particular COVA1-16, to enhance neutralization of SARS-CoV-2 and SARS-CoV. Overall, this study provides valuable information for vaccine and therapeutic design to address current and future antigenic drift in SARS-CoV-2 and to protect against zoonotic coronaviruses.
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Xueyong Zhu. (2021, Nov 6).A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection[Video]. Scitok. https://scitok.com/project/p/9da65796
Liu Hejun. "A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection" Scitok, uploaded by Zhu Xueyong, 6 Nov, 2021, https://scitok.com/project/p9da65796
Xueyong Zhu. "A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection" Scitok. (Nov 6, 2021). https://scitok.com/project/p/9da65796
Xueyong Zhu (Nov 6, 2021). A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection Scitok. https://scitok.com/project/p/9da65796
Xueyong Zhu. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection[video]. 2021 Nov 6. https://scitok.com/project/p/9da65796
@online{al2006link, title={ A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection }, author={ Zhu, Xueyong }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/9da65796}, }