Author(s)
Maria R. Capobianchi
Published 5 Projects
Immunology SARS-CoV-2 Bioinformatics Biochemistry Infectious Diseases
Content
Video Abstract (AI generated) (01:29) Paper PreprintCoronaviruses (CoV) are a large family of enveloped, RNA viruses that circulate in mammals and birds. Three highly pathogenic strains have caused zoonotic infections in humans that result in severe respiratory syndromes including the Middle East Respiratory Syndrome CoV (MERS), Severe Acute Respiratory Syndrome CoV (SARS), and the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. Here, we describe a panel of synthetic monoclonal antibodies, built on a human IgG framework, that bind to the spike protein of SARS-CoV-2 (the causative agent of COVID-19), compete for ACE2 binding, and potently inhibit SARS-CoV-2. All antibodies that exhibited neutralization potencies at sub-nanomolar concentrations against SARS-CoV-2/USA/WA1 in Vero E6 cells, also bound to the receptor binding domain (RBD), suggesting competition for the host receptor ACE2. These antibodies represent strong immunotherapeutic candidates for treatment of COVID-19. ### Competing Interest Statement S.S, P.P.P and S.J, are cofounders of Virna Therapeutics. The company is developing novel therapies for COVID-19 and other viruses.
More Projects
Loren Frank
13 views • 2 years ago
Global Immunotalks
390 views • 3 years ago
Laurel Yohe
2 views • 2 years ago
Global Immunotalks
130 views • 3 years ago
Jignesh H. Parmar
0 views • 2 years ago
Winston A. Haynes
0 views • 2 years ago
Noam Mazor
0 views • 2 years ago
Global Immunotalks
182 views • 3 years ago
Cem Yuksel
345 views • 3 years ago
Oscar Gonzalez-Recio
3 views • 2 years ago
Please pick a style:
Maria R. Capobianchi. (2021, Oct 23).Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells[Video]. Scitok. https://scitok.com/project/p/a735b172
Miersch Shane. "Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells" Scitok, uploaded by R. Capobianchi Maria, 23 Oct, 2021, https://scitok.com/project/pa735b172
Maria R. Capobianchi. "Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells" Scitok. (Oct 23, 2021). https://scitok.com/project/p/a735b172
Maria R. Capobianchi (Oct 23, 2021). Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells Scitok. https://scitok.com/project/p/a735b172
Maria R. Capobianchi. Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells[video]. 2021 Oct 23. https://scitok.com/project/p/a735b172
@online{al2006link, title={ Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells }, author={ R. Capobianchi, Maria }, organization={Scitok}, month={ Oct }, day={ 23 }, year={ 2021 }, url = {https://scitok.com/project/p/a735b172}, }