Author(s)
Greg McInnes
Published 5 Projects
genomics Bioinformatics Genetics Health Systems And Quality Improvement
Russ Altman
Published 17 Projects
Through Manual Identification And Other In The United States In This Paper Singapore
Content
Pharmacogenetics studies how genetic variation leads to variability in drug response. Guidelines for selecting the right drug and right dose to patients based on their genetics are clinically effective, but are still widely unused. For some drugs, the normal clinical decision making process may lead to the optimal dose of a drug that minimizes side effects and maximizes effectiveness. Without measurements of genotype, physicians and patients may observe and adjust dosage in a manner that reflects the underlying genetics. The emergence of genetic data linked to longitudinal clinical data in large biobanks offers an opportunity to confirm known pharmacogenetic interactions as well as discover novel associations by investigating outcomes from normal clinical practice. Here we use the UK Biobank to search for pharmacogenetic interactions among 200 drugs and 9 genes among 200,000 participants. We identify associations between pharmacogene phenotypes and drug maintenance dose as well as side effect incidence. We find support for several known drug-gene associations as well as novel pharmacogenetic interactions. ### Competing Interest Statement R.B.A. is a stockholder in Personalis.com, 23andme.com.
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Russ Altman. (2021, Oct 26).Drug Response Pharmacogenetics for 200,000 UK Biobank Participants[Video]. Scitok. https://scitok.com/project/p/c606203a
McInnes Greg. "Drug Response Pharmacogenetics for 200,000 UK Biobank Participants" Scitok, uploaded by Altman Russ, 26 Oct, 2021, https://scitok.com/project/pc606203a
Russ Altman. "Drug Response Pharmacogenetics for 200,000 UK Biobank Participants" Scitok. (Oct 26, 2021). https://scitok.com/project/p/c606203a
Russ Altman (Oct 26, 2021). Drug Response Pharmacogenetics for 200,000 UK Biobank Participants Scitok. https://scitok.com/project/p/c606203a
Russ Altman. Drug Response Pharmacogenetics for 200,000 UK Biobank Participants[video]. 2021 Oct 26. https://scitok.com/project/p/c606203a
@online{al2006link, title={ Drug Response Pharmacogenetics for 200,000 UK Biobank Participants }, author={ Altman, Russ }, organization={Scitok}, month={ Oct }, day={ 26 }, year={ 2021 }, url = {https://scitok.com/project/p/c606203a}, }