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There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent virus dissemination; in the present pandemic context, drug repurposing is a priority. Targeting the nucleoprotein N of the SARS-CoV-2 coronavirus in order to inhibit its association with viral RNA could be a strategy to impeding viral replication and possibly other essential functions associated with viral N. The antiviral properties of naproxen, belonging to the NSAID family, previously demonstrated against Influenza A virus, were evaluated against SARS-CoV-2. Naproxen binding to the nucleoprotein of SARS-CoV2 was shown by molecular modeling. In VeroE6 cells and reconstituted human primary respiratory epithelium models of SARS-CoV-2 infection, naproxen inhibited viral replication and protected the bronchial epithelia against SARS-CoV-2 induced-damage. The benefit of naproxen addition to the standard of care is tested in an on-going clinical study. ### Competing Interest Statement The authors have declared no competing interest.
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Anny Slama Schwok. (2021, Oct 1).Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus[Video]. Scitok. https://scitok.com/project/p/cd1b6269
Terrier Olivier. "Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus" Scitok, uploaded by Slama Schwok Anny, 1 Oct, 2021, https://scitok.com/project/pcd1b6269
Anny Slama Schwok. "Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus" Scitok. (Oct 1, 2021). https://scitok.com/project/p/cd1b6269
Anny Slama Schwok (Oct 1, 2021). Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus Scitok. https://scitok.com/project/p/cd1b6269
Anny Slama Schwok. Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus[video]. 2021 Oct 1. https://scitok.com/project/p/cd1b6269
@online{al2006link, title={ Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus }, author={ Slama Schwok, Anny }, organization={Scitok}, month={ Oct }, day={ 1 }, year={ 2021 }, url = {https://scitok.com/project/p/cd1b6269}, }