Author(s)
William T Lee
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Roxanne C. Girardin
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Alan P. Dupuis
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Karen E Kulas
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Anne F. Payne
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Susan J Wong
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Suzanne Arinsburg
Published 3 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Freddy T Nguyen
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Damodara Rao Mendu
Published 5 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Adolfo Firpo-Betancourt
Published 2 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Ania Wajnberg
Published 4 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Carlos Cordon-Cardo
Published 5 Projects
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Sherlita Amler
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Marisa A Montecalvo
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Brad Hutton
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Jill Taylor
Published 1 Project
COVID-19 SARS-CoV-2 Infectious Diseases Key Words Convalescent Plasma
Content
Passive transfer of antibodies from COVID-19 convalescent patients is being used as an experimental treatment for eligible patients with SARS-CoV-2 infections. The United States Food and Drug Administration's (FDA) guidelines for convalescent plasma recommends target antibody titers of 160. We evaluated SARS-CoV-2 neutralizing antibodies in sera from recovered COVID-19 patients using plaque reduction neutralization tests (PRNT) at low (PRNT50) and high (PRNT90) stringency thresholds. We found that neutralizing activity increased with time post symptom onset (PSO), reaching a peak at 31-35 days PSO. At this point, the number of sera having neutralizing titers of at least 160 was ~93% (PRNT50) and ~54% (PRNT90). Sera with high SARS-CoV-2 antibody levels ([≥]960 ELISA titers) showed maximal activity, but not all high titer sera contained neutralizing antibody at FDA recommended levels, particularly at high stringency. These results underscore the value of serum characterization for neutralization activity.
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Florian Krammer. (2021, Oct 30).Neutralizing Antibody Responses in COVID-19 Convalescent Sera[Video]. Scitok. https://scitok.com/project/p/cf8a71e2
T Lee William. "Neutralizing Antibody Responses in COVID-19 Convalescent Sera" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/pcf8a71e2
Florian Krammer. "Neutralizing Antibody Responses in COVID-19 Convalescent Sera" Scitok. (Oct 30, 2021). https://scitok.com/project/p/cf8a71e2
Florian Krammer (Oct 30, 2021). Neutralizing Antibody Responses in COVID-19 Convalescent Sera Scitok. https://scitok.com/project/p/cf8a71e2
Florian Krammer. Neutralizing Antibody Responses in COVID-19 Convalescent Sera[video]. 2021 Oct 30. https://scitok.com/project/p/cf8a71e2
@online{al2006link, title={ Neutralizing Antibody Responses in COVID-19 Convalescent Sera }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/cf8a71e2}, }