Author(s)
Chimota Phiri
Published 3 Projects
COVID-19 Immunology SARS-CoV-2 Biochemistry Public And Global Health
Content
Video Abstract (AI generated) (01:48) Paper PreprintIntroduction: Iron deficiency is a treatable cause of severe anaemia in low-and-middle-income-countries (LMIC). Diagnosing it remains challenging as peripheral blood markers poorly reflect bone-marrow iron deficiency (BM-ID), especially in the context of HIV-infection. Methods: Severe anaemic (haemoglobin ≤70g/l) HIV-infected adults were recruited at Queen Elizabeth Central Hospital, Blantyre, Malawi. BM-ID was evaluated. Accuracy of blood markers including hepcidin alongside mean corpuscular volume, mean cellular haemoglobin concentration, serum iron, serum ferritin, soluble transferrin receptor (sTfR), sTfR -index, sTfR –ratio to detect BM-ID was valued by ROC area under the curve (AUCROC ). Results: Seventy-three patients were enrolled and 35 (48.0%) had BM-ID. Hepcidin and MCV performed best; AUCROC of 0.593 and 0.545. Other markers performed poorly (ROC<0.5). The AUCROC of hepcidin in males was 0.767 (sensitivity 80%, specificity 78%) and in women 0.490 (sensitivity 60%, specificity 61%). Conclusion: BM-ID deficiency was common in severely anaemic HIV-infected patients and is an important and potential treatable contributor to severe anaemia. Hepcidin was the best, though still suboptimal, marker of BM-ID. Hepcidin, which is directly linked to iron absorption, is a very promising marker to guide curative iron supplementation policies in severely anaemic HIV-infected patients.
More Projects
Loren Frank
13 views • 2 years ago
Global Immunotalks
390 views • 3 years ago
Laurel Yohe
2 views • 2 years ago
Global Immunotalks
130 views • 3 years ago
Jignesh H. Parmar
0 views • 2 years ago
Winston A. Haynes
0 views • 2 years ago
Noam Mazor
0 views • 2 years ago
Global Immunotalks
182 views • 3 years ago
Cem Yuksel
345 views • 3 years ago
Oscar Gonzalez-Recio
3 views • 2 years ago
Please pick a style:
Chimota Phiri. (2021, Nov 5).Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi[Video]. Scitok. https://scitok.com/project/p/d1e1919a
HW Huibers Minke. "Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi" Scitok, uploaded by Phiri Chimota, 5 Nov, 2021, https://scitok.com/project/pd1e1919a
Chimota Phiri. "Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi" Scitok. (Nov 5, 2021). https://scitok.com/project/p/d1e1919a
Chimota Phiri (Nov 5, 2021). Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi Scitok. https://scitok.com/project/p/d1e1919a
Chimota Phiri. Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi[video]. 2021 Nov 5. https://scitok.com/project/p/d1e1919a
@online{al2006link, title={ Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi }, author={ Phiri, Chimota }, organization={Scitok}, month={ Nov }, day={ 5 }, year={ 2021 }, url = {https://scitok.com/project/p/d1e1919a}, }