Author(s)
Khushboo Bafna
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Kris M White
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Balasubramanian Harish
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Romel Rosales
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Theresa A Ramelot
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Thomas B. Acton
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Elena Moreno
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Thomas Kehrer
Published 2 Projects
COVID-19 Biochemistry Infectious Diseases Key Words Sars Cov 2 Pl Protease
Catherine A. Royer
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Adolfo GarcĂa-Sastre
Published 9 Projects
COVID-19 Microbiology Biochemistry Infectious Diseases Allergy And Immunology
Robert M Krug
Published 1 Project
COVID-19 Biochemistry Key Words Sars Cov 2 Pl Protease Sars Cov 2 3Clmpro Protease
Gaetano Montelione
Published 2 Projects
COVID-19 Microbiology Biochemistry Key Words Sars Cov 2 Pl Protease
Content
Video Abstract (AI generated) (01:19) Paper PreprintEffective control of COVID-19 requires antivirals directed against SARS-CoV-2 virus. Here we assess ten available HCV protease inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2 Mpro and HCV NS3/4A proteases, and virtual docking experiments show that all ten HCV drugs can potentially bind into the Mpro binding cleft. Seven of these HCV drugs inhibit SARS-CoV-2 Mpro protease activity, while four dock well into the PLpro substrate binding cleft and inhibit PLpro protease activity. These same seven HCV drugs inhibit SARS-CoV-2 virus replication in Vero and/or human cells, demonstrating that HCV drugs that inhibit Mpro, or both Mpro and PLpro, suppress virus replication. Two HCV drugs, simeprevir and grazoprevir synergize with the viral polymerase inhibitor remdesivir to inhibit virus replication, thereby increasing remdesivir inhibitory activity as much as 10-fold.
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Gaetano Montelione. (2021, Nov 2).Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture[Video]. Scitok. https://scitok.com/project/p/d5f9d179
Bafna Khushboo. "Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture" Scitok, uploaded by Montelione Gaetano, 2 Nov, 2021, https://scitok.com/project/pd5f9d179
Gaetano Montelione. "Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture" Scitok. (Nov 2, 2021). https://scitok.com/project/p/d5f9d179
Gaetano Montelione (Nov 2, 2021). Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture Scitok. https://scitok.com/project/p/d5f9d179
Gaetano Montelione. Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture[video]. 2021 Nov 2. https://scitok.com/project/p/d5f9d179
@online{al2006link, title={ Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture }, author={ Montelione, Gaetano }, organization={Scitok}, month={ Nov }, day={ 2 }, year={ 2021 }, url = {https://scitok.com/project/p/d5f9d179}, }