Seroprevalence of SARS-CoV-2 among children visiting a hospital during the initial Seattle outbreak

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Author Name

Adam S Dingens

Andrea N Loes

Amanda Adler

Published 1 Project

Infectious Diseases

Sarah L Steele

Published 1 Project

Infectious Diseases

Kirsten Lacombe

Published 1 Project

Infectious Diseases

Rachel Eguia

Alexandra C. Walls

Caitlin R Wolf

Michael Murphy

Deleah Pettie

Lauren Carter

Published 2 Projects

Immunology Infectious Diseases

Xuan Qin

Published 1 Project

Infectious Diseases

Neil P. King

David Veesler


Florian Krammer

Jane A Dickerson

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Infectious Diseases

Helen Y Chu

Janet A Englund

Published 1 Project

Infectious Diseases

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Children are strikingly underrepresented in COVID-19 case counts. In the United States, children represent 22% of the population but only 1.7% of confirmed SARS-CoV-2 cases. One possibility is that symptom-based viral testing is less likely to identify infected children, since they often experience milder disease than adults. To better assess the frequency of pediatric SARS-CoV-2 infection, we serologically screened 1,775 residual samples from Seattle Children's Hospital collected from 1,076 children seeking medical care during March and April of 2020. Only one child was seropositive in March, but nine were seropositive in April for a period seroprevalence of >1%. Most seropositive children (8/10) were not suspected of having had COVID-19. The sera of most seropositive children had neutralizing activity, including one that neutralized at a dilution >1:18,000. Therefore, among children seeking medical care, the frequency of SARS-CoV-2 infection increased markedly during the early Seattle outbreak despite few positive viral tests.

Infectious Diseases
Infectious Diseases 62 Projects