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Kirstie J. Whitaker
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the NSPN Consortium
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Edward T. Bullmore
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Video Abstract (AI generated) (01:35) Paper Preprint NeuroImageComplex network topology is characteristic of many biological systems, including anatomical and functional brain networks (connectomes). Here, we first constructed a structural covariance network (SCN) from MRI measures of cortical thickness on 296 healthy volunteers, aged 14-24 years. Next, we designed a new algorithm for matching sample locations from the Allen Brain Atlas to the nodes of the SCN. Subsequently we use this to define, transcriptomic brain networks (TBN) by estimating gene co-expression between pairs of cortical regions. Finally, we explore the hypothesis that TBN and the SCN are coupled. TBN and SCN were correlated across connection weights and showed qualitatively similar complex topological properties. There were differences between networks in degree and distance distributions. However, cortical areas connected to each other within modules of the SCN network had significantly higher levels of whole genome co-expression than expected by chance. Nodes connected in the SCN had significantly higher levels of expression and co-expression of a Human Supragranular Enriched (HSE) gene set that are known to be important for large-scale cortico-cortical connectivity. This coupling of brain transcriptome and connectome topologies was largely but not completely related to the common constraint of physical distance on both networks.
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Petra E VĂ©rtes. (2021, Nov 9).Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex[Video]. Scitok. https://scitok.com/project/p/e3d0054f
Romero-Garcia Rafael. "Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex" Scitok, uploaded by E VĂ©rtes Petra, 9 Nov, 2021, https://scitok.com/project/pe3d0054f
Petra E VĂ©rtes. "Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex" Scitok. (Nov 9, 2021). https://scitok.com/project/p/e3d0054f
Petra E VĂ©rtes (Nov 9, 2021). Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex Scitok. https://scitok.com/project/p/e3d0054f
Petra E VĂ©rtes. Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex[video]. 2021 Nov 9. https://scitok.com/project/p/e3d0054f
@online{al2006link, title={ Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex }, author={ E VĂ©rtes, Petra }, organization={Scitok}, month={ Nov }, day={ 9 }, year={ 2021 }, url = {https://scitok.com/project/p/e3d0054f}, }