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Video Abstract (AI generated) (00:42) Paper PreprintProtein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates arginine residues of histone H3 and non-histone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and potentially therapeutics. While several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Here, we report the structure-based design of a new class of alanine containing 3-arylindoles as potent and selective PRMT4 inhibitors and describe key structure activity relationships for this class of compounds. ### Competing Interest Statement The authors have declared no competing interest.
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Fengling Li. (2021, Sep 30).Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics[Video]. Scitok. https://scitok.com/project/p/e838bd2d
Sutherland Mathew. "Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics" Scitok, uploaded by Li Fengling, 30 Sep, 2021, https://scitok.com/project/pe838bd2d
Fengling Li. "Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics" Scitok. (Sep 30, 2021). https://scitok.com/project/p/e838bd2d
Fengling Li (Sep 30, 2021). Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics Scitok. https://scitok.com/project/p/e838bd2d
Fengling Li. Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics[video]. 2021 Sep 30. https://scitok.com/project/p/e838bd2d
@online{al2006link, title={ Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics }, author={ Li, Fengling }, organization={Scitok}, month={ Sep }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/e838bd2d}, }