Author(s)
Prasanth Manohar
Published 6 Projects
Microbiology Evolution Bioinformatics 1. Introduction Introduction
Ramesh Nachimuthu
Published 5 Projects
Microbiology 1. Introduction Introduction 10 Introduction Carbapenem
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Video Abstract (AI generated) (01:33) Paper PreprintThe distribution of carbapenem-resistant Gram-negative bacteria has become an increasing public health concern in India. The aim of this study was to investigate the prevalence of carbapenem-resistant bacteria isolated from the clinical samples in Tamil Nadu, India. A total of 126 non-repetitive Gram-negative bacteria were taken for this study. The susceptibility to meropenem was determined by Minimum Inhibitory Concentration (MIC) by broth microdilution. The phenotypic resistance screening such as MHT (Modified Hodge test), EDTA disk synergy and CIM (carbapenem inactivation method) were performed. A multiplex PCR was used for the detection of carbapenemase-encoding genes. Among the 126 isolates studied, 82 (65.07%) meropenem-resistant isolates were identified by MIC. A total of 18 (21.9%) isolates were found to be positive for Metallo-{beta}-Lactamase production through EDTA synergy test. None of the isolates were carbapenemase producer by MHT and CIM. The isolates identified with resistance genes (8/82) were blaNDM-1 in two Klebsiella sp., two P. aeruginosa and one A. baumannii, blaVIM-1 in one P. aeruginosa and blaAIM-1 in one P. aeruginosa and one A. baumannii. The study showed the distribution and increase of carbapenem-resistant bacteria in the study region. Therefore, constant monitoring and effective elimination should be focused to reduce the spread of carbapenem-resistant isolates.
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Prasanth Manohar. (2021, Nov 7).Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu[Video]. Scitok. https://scitok.com/project/p/e87076c0
Manohar Prasanth. "Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu" Scitok, uploaded by Manohar Prasanth, 7 Nov, 2021, https://scitok.com/project/pe87076c0
Prasanth Manohar. "Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu" Scitok. (Nov 7, 2021). https://scitok.com/project/p/e87076c0
Prasanth Manohar (Nov 7, 2021). Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu Scitok. https://scitok.com/project/p/e87076c0
Prasanth Manohar. Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu[video]. 2021 Nov 7. https://scitok.com/project/p/e87076c0
@online{al2006link, title={ Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu }, author={ Manohar, Prasanth }, organization={Scitok}, month={ Nov }, day={ 7 }, year={ 2021 }, url = {https://scitok.com/project/p/e87076c0}, }